{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:48:53Z","timestamp":1780483733847,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During unilateral static and rhythmic handgrip exercise, middle cerebral artery blood velocity (MCAv) increases in the contralateral side to the exercising limb. However, whether this neurovascular coupling\u2010mediated increase in contralateral MCAv is apparent against a background of fluctuating perfusion pressure produced by dynamic resistance exercise (RE) is unclear. We examined the cerebral haemodynamic response to unilateral dynamic RE in 30 healthy individuals (female\u00a0=\u00a016, mean\u00a0\u00b1\u00a0SD: age, 26\u00a0\u00b1\u00a06 years; height, 175\u00a0\u00b1\u00a010\u00a0cm; weight, 74\u00a0\u00b1\u00a015\u00a0kg; body mass index, 24\u00a0\u00b1\u00a05\u00a0kg\u00a0m<jats:sup>\u22122<\/jats:sup>). Participants completed four sets of 10 paced repetitions (15 repetitions\u00a0min<jats:sup>\u22121<\/jats:sup>) of unilateral bicep curl exercise at 60% of the predicted one\u2010repetition maximum (7\u00a0\u00b1\u00a03\u00a0kg). Beat\u2010to\u2010beat blood pressure, bilateral MCAv and end\u2010tidal carbon dioxide were measured throughout. One\u2010way ANOVA was used to analyse cardiovascular variables and two\u2010way ANOVA to analyse dependent cerebrovascular variables (side\u00a0\u00d7\u00a0sets, 2\u00a0\u00d7\u00a05). A linear mixed model analysis was also performed to investigate the effects of end\u2010tidal carbon dioxide and mean arterial blood pressure on MCAv. In comparison to baseline, within\u2010exercise mean arterial blood pressure increased (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) across the sets, whereas bilateral MCAv decreased (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). However, no significant interaction effect was observed for any dependent variables (all <jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.787). The linear mixed model revealed that end\u2010tidal carbon dioxide had the greatest effect on MCAv (estimate\u00a0=\u00a01.019, <jats:italic>t<\/jats:italic>\u00a0=\u00a08.490, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). No differences were seen in contralateral and ipsilateral MCAv during dynamic RE, suggesting that neurovascular coupling contributions during dynamic RE might be masked by other regulators, such as blood pressure.<\/jats:p>","DOI":"10.1113\/ep091970","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T12:51:28Z","timestamp":1727268688000},"page":"2017-2025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neurovascular coupling during dynamic upper body resistance exercise in healthy individuals"],"prefix":"10.1113","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5411-1412","authenticated-orcid":false,"given":"Stephanie","family":"Korad","sequence":"first","affiliation":[{"name":"School of Health Sciences Massey University  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4214-8543","authenticated-orcid":false,"given":"Toby","family":"M\u00fcndel","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Nutrition Massey University  Palmerston North New Zealand"},{"name":"Department of Kinesiology Brock University  St Catharines Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-519X","authenticated-orcid":false,"given":"Blake G.","family":"Perry","sequence":"additional","affiliation":[{"name":"School of Health Sciences Massey University  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1081","volume-title":"Transcranial Doppler ultrasound: Valid, invalid, or both?","author":"Ainslie P. 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