{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:28:44Z","timestamp":1791001724279,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to determine the difference in motor unit (MU) firing pattern between hypertensive and normotensive individuals, and the relationship between MU firing pattern and post\u2010exercise blood pressure (BP) response in older individuals. Fourteen older untreated (systolic\/diastolic BP (SBP\/DBP)\u00a0\u2265\u00a0130\/80\u00a0mmHg, 76 (5) years), 11 treated hypertensive (78 (4) years) and 14 normotensive (SBP\/DBP\u00a0&lt;\u00a0130\/80\u00a0mmHg, 71 (4) years) individuals were studied. Participants performed ramp\u2010up exercises until 50% of maximal voluntary contraction (MVC) of knee extension and five MVCs. During the ramp\u2010up exercise, high\u2010density surface electromyography signals were recorded and each MU firing rate (FR) and recruitment threshold was assessed. The slope of the linear regression between MUFRs and recruitment thresholds was calculated to assess the MU firing pattern. Pre\u2010 and post\u2010exercise blood pressure was measured. Change in (\u2206)SBP from pre\u2010 to post\u2010exercise was greater in treated hypertensive than untreated hypertensive individuals (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.026). MUFR was lower in treated hypertensive than untreated hypertensive and normotensive individuals (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Although the slope was not significantly different between groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.294), FRs of larger MUs were lower than those of smaller MUs in treated hypertensive and normotensive individuals (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) but sustained in untreated hypertensive individuals. The FRs of larger MUs and slope were positively correlated with the \u2206SBP only in hypertensive individuals (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.768 and 0.715; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.044 and 0.020). MUFR was lower in treated hypertensive than untreated hypertensive and normotensive individuals. Furthermore, MU firing patterns were associated with the \u2206SBP after exercise in older untreated hypertensive individuals, but this relationship was not observed in treated hypertensive and normotensive individuals.<\/jats:p>","DOI":"10.1113\/ep091981","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T02:45:27Z","timestamp":1730256327000},"page":"307-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in motor unit firing pattern are associated with post\u2010exercise blood pressure response in older untreated but not treated hypertensive adults"],"prefix":"10.1113","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6535-0912","authenticated-orcid":false,"given":"Ryosuke","family":"Takeda","sequence":"first","affiliation":[{"name":"Laboratory of Neuromuscular Biomechanics School of Health and Sport Science Chukyo University  Toyota Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4337-6249","authenticated-orcid":false,"given":"Tetsuya","family":"Hirono","sequence":"additional","affiliation":[{"name":"Laboratory of Neuromuscular Biomechanics School of Health and Sport Science Chukyo University  Toyota Japan"},{"name":"Research Fellow of Japan Society for the Promotion of Science  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8929-9202","authenticated-orcid":false,"given":"Akito","family":"Yoshiko","sequence":"additional","affiliation":[{"name":"Faculty of Liberal Arts and Sciences Chukyo University  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Kunugi","sequence":"additional","affiliation":[{"name":"Center for General Education Aichi Institute of Technology  Toyota Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Okudaira","sequence":"additional","affiliation":[{"name":"Laboratory of Neuromuscular Biomechanics School of Health and Sport Science Chukyo University  Toyota Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeko","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition School of Life Studies Sugiyama Jogakuen University  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Laboratory of Neuromuscular Biomechanics School of Health and Sport Science Chukyo University  Toyota Japan"},{"name":"Graduate School of Health and Sport Sciences Chukyo University  Toyota Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8918-5181","authenticated-orcid":false,"given":"Kohei","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Laboratory of Neuromuscular Biomechanics School of Health and Sport Science Chukyo University  Toyota Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.507"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.11.018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00546.2011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.35.6.845"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.36.2.174"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11076"},{"key":"e_1_2_9_8_1","first-page":"H1523","article-title":"Baroreflex regulation of forearm vascular resistance after exercise in hypertensive and normotensive humans","volume":"263","author":"Cleroux J.","year":"1992","journal-title":"American Journal of Physiology"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00490.2018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66104-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00556.2010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01018.2009"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200434120-00002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1985.tb07715.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.10.040"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90219.2008"},{"key":"e_1_2_9_17_1","first-page":"253","article-title":"Absence of post exercise hypotension and sympathoinhibition in normal subjects: Additional evidence for increased sympathetic outflow in borderline hypertension","volume":"7","author":"Floras J. 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