{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:09:16Z","timestamp":1791929356925,"version":"4.3.4"},"reference-count":66,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A significant increase in circulating cell\u2010free DNA (cfDNA) occurs with physical exercise, which depends on the type of exertion and the duration. The aims of this study were as follows: (1) to investigate the time course of cfDNA and conventional markers of muscle damage from immediately after to 96\u00a0h after muscle\u2010damaging exercise; and (2) to investigate the relationship between cfDNA and indicators of primary (low\u2010frequency fatigue and maximal voluntary isometric contraction) and secondary (creatine kinase and delayed\u2010onset muscle soreness) muscle damage in young healthy males. Fourteen participants (age, 22\u00a0\u00b1\u00a02\u00a0years; weight, 84.4\u00a0\u00b1\u00a011.2\u00a0kg; height, 184.0\u00a0\u00b1\u00a07.4\u00a0cm) performed 50 intermittent drop jumps at 20\u00a0s intervals. We measured cfDNA and creatine kinase concentrations, maximal voluntary isometric contraction torque, low\u2010frequency fatigue and delayed\u2010onset muscle soreness before and at several time points up to 96\u00a0h after exercise. Plasma cfDNA levels increased from immediately postexercise until 72\u00a0h postexercise (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Elevation of postexercise cfDNA was correlated with both more pronounced low\u2010frequency fatigue (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.52, <jats:italic>P<\/jats:italic>\u00a0=\u00a03.4\u00a0\u00d7\u00a010<jats:sup>\u221211<\/jats:sup>) and delayed\u2010onset muscle soreness (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.32, <jats:italic>P<\/jats:italic>\u00a0= 0.00019). Levels of cfDNA change in response to severe primary and secondary muscle damage after exercise. Levels of cfDNA exhibit a stronger correlation with variables related to primary muscle damage than to secondary muscle damage, suggesting that cfDNA is a more sensitive marker of acute loss of muscle function than of secondary inflammation or damaged muscle fibres.<\/jats:p>","DOI":"10.1113\/ep091986","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T16:23:56Z","timestamp":1718382236000},"page":"1341-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cell\u2010free DNA kinetics in response to muscle\u2010damaging exercise: A drop jump study"],"prefix":"10.1113","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6589-5843","authenticated-orcid":false,"given":"Ema","family":"Ju\u0161kevi\u010di\u016bt\u0117","sequence":"first","affiliation":[{"name":"Institute of Sport Science and Innovations Lithuanian Sports University  Kaunas Lithuania"},{"name":"Department 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