{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:39:02Z","timestamp":1781937542006,"version":"3.54.5"},"reference-count":70,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maternal asthma is associated with increased rates of neonatal lung disease, and fetuses from asthmatic ewes have fewer surfactant\u2010producing cells and lower surfactant\u2010protein B gene (<jats:italic>SFTPB<\/jats:italic>) expression than controls. Antenatal betamethasone increases lung surfactant production in preterm babies, and we therefore tested this therapy in experimental maternal asthma. Ewes were sensitised to house dust mite allergen, and an asthmatic phenotype induced by fortnightly allergen lung challenges; controls received saline. Pregnant asthmatic ewes were randomised to receive antenatal saline (asthma) or 12\u00a0mg intramuscular betamethasone (asthma+beta) at 138 and 139 days of gestation (term\u00a0=\u00a0150 days). Lambs were delivered by Caesarean section at 140 days of gestation and ventilated for 45\u00a0min before tissue collection. Lung function and structure were similar in control lambs (<jats:italic>n<\/jats:italic>\u00a0=\u00a016, 11 ewes) and lambs from asthma ewes (<jats:italic>n<\/jats:italic>\u00a0=\u00a014, 9 ewes). Dynamic lung compliance was higher in lambs from asthma+beta ewes (<jats:italic>n<\/jats:italic>\u00a0=\u00a012, 8 ewes) compared to those from controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) or asthma ewes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Lung expression of surfactant protein genes <jats:italic>SFTPA<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.048) and <jats:italic>SFTPB<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), but not <jats:italic>SFTPC<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.177) or <jats:italic>SFTPD<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.285), was higher in lambs from asthma+beta than those from asthma ewes. Female lambs had higher tidal volume (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007), dynamic lung compliance (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and <jats:italic>SFTPA<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.037) and <jats:italic>SFTPB<\/jats:italic> gene expression (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.030) than males. These data suggest that betamethasone stimulates lung maturation and function of near\u2010term neonates, even in the absence of impairment by maternal asthma.<\/jats:p>","DOI":"10.1113\/ep091997","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T15:13:59Z","timestamp":1729610039000},"page":"1967-1979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Betamethasone improved near\u2010term neonatal lamb lung maturation in experimental maternal asthma"],"prefix":"10.1113","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-1496","authenticated-orcid":false,"given":"Joshua L.","family":"Robinson","sequence":"first","affiliation":[{"name":"Robinson Research Institute University of Adelaide  Adelaide South Australia Australia"},{"name":"Adelaide Medical School University of Adelaide  Adelaide South Australia Australia"},{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2560-7629","authenticated-orcid":false,"given":"Andrea J.","family":"Roff","sequence":"additional","affiliation":[{"name":"Robinson Research Institute University of Adelaide  Adelaide South Australia Australia"},{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"},{"name":"School of Biomedicine University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Hammond","sequence":"additional","affiliation":[{"name":"Robinson Research Institute University of Adelaide  Adelaide South Australia Australia"},{"name":"Early Origins of Adult Health Research Group, Health and Biomedical Innovation, Clinical and Health Sciences University of South Australia  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-3920","authenticated-orcid":false,"given":"Jack R. 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