{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:44:52Z","timestamp":1780584292343,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obstructive sleep apnoea (OSA) is a prevalent cardiorespiratory disorder associated with significant neurocognitive consequences. Despite the higher prevalence of OSA in men, there is a strong association between OSA and Alzheimer's disease (AD), which disproportionately affects women. This study aimed to investigate the impact of chronic intermittent hypoxia (CIH), a hallmark of OSA, on cognitive function and AD markers in ovariectomized, female rats. At 8\u00a0weeks of age, 16 Sprague\u2013Dawley rats underwent ovariectomy and were exposed to CIH for 26\u00a0weeks. Cognitive function was assessed using the Morris water maze, revealing significant deficits in spatial learning (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001) and memory (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008) in CIH\u2010exposed rats, compared to controls. Analysis of hippocampal tissue showed increased total tau protein (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0078), indicative of AD pathology. Additionally, CIH\u2010exposed rats exhibited respiratory dysfunction characterized by increased frequency of apnoeas (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0328). These findings provide preclinical evidence of the association between OSA, cognitive decline and AD pathology in females, emphasizing the importance of sex\u2010specific research in understanding and addressing these pathophysiological interconnections.<\/jats:p>","DOI":"10.1113\/ep092018","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T11:45:59Z","timestamp":1747655159000},"page":"1154-1163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic intermittent hypoxia\u2010mediated cognitive dysfunction in ovariectomized rats"],"prefix":"10.1113","volume":"110","author":[{"given":"Emily C.","family":"Cheung","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology George Washington University Washington District of Columbia USA"},{"name":"Department of Biomedical Engineering George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan B.","family":"Escobar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget R.","family":"Alber","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishan","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Kowalik","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grey","family":"Harral","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makeda","family":"Melkie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Ketzenberger","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bethea","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vsevolod Y","family":"Polotsky","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Medicine George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Schunke","sequence":"additional","affiliation":[{"name":"Department of Cell &amp; 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