{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:13:00Z","timestamp":1747195980629,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010altitude exercise affects cardiac function. This study investigated how altitude and exercise intensity interacted to affect cardiac function of Sprague\u2010Dawley rats. Four altitudes (410, 3600, 4600 and 5600\u00a0m) and three exercise intensities (non\u2010exercise (N), low\u2010intensity exercise (L) and high\u2010intensity exercise (H)) were tested combinatorically. After 4\u00a0weeks of exercise, cardiac function and specific markers of myocardial injury were assessed. With regard to cardiac function, (a) at the same intensity, stroke volume and left ventricular end\u2010diastolic volume were higher in the 3600\u00a0m group but lower in the 4600 and 5600\u00a0m groups; and (b) the heart rate increased with altitude and intensity. The biochemical results showed that the levels of creatine kinase, myoglobin and cardiac troponin I generally increased with increasing altitude and exercise intensity, significantly for creatine kinase and myoglobin at 4600 and 5600\u00a0m. For pathological results, (a) in the non\u2010exercise group, pathological damage was observed only in the 5600 N group; and (b) in the exercised state, varying degrees of injury were noted, except for the 410 and 3600 L groups. There may be a turning point at 3600\u00a0m where the injury to the heart increases. Myocardial injury markers exhibited abnormalities before cardiac dysfunction. Detecting these markers is crucial to provide warnings for the individual from cardiac disease during high\u2010altitude exercise.<\/jats:p>","DOI":"10.1113\/ep092037","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T17:09:11Z","timestamp":1727370551000},"page":"735-743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of altitude and exercise intensity on cardiac function in rats"],"prefix":"10.1113","volume":"110","author":[{"given":"Minxia","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine Xizang Minzu University  Xianyang Shaanxi P. R. China"},{"name":"Xizang Minzu University  Xianyang Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[{"name":"Xizang Minzu University  Xianyang Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"Xizang Minzu University  Xianyang Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of High Altitude Hypoxia Environment and Life Health, School of Medicine Xizang Minzu University  Xianyang Shaanxi P. R. China"},{"name":"Xizang Minzu University  Xianyang Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Xizang Minzu University  Xianyang Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Xizang Minzu University  Xianyang Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengru","family":"Duan","sequence":"additional","affiliation":[{"name":"Xizang Minzu University  Xianyang Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Xizang Minzu University  Xianyang Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.773"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"776","article-title":"Increased hypoxic dose after training at low altitude with 9\u00a0h per night at 3000 m normobaric hypoxia","volume":"14","author":"Carr A. 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