{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:17:49Z","timestamp":1782760669581,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD34<jats:sup>+<\/jats:sup> progenitor cells with angiogenic capabilities traffic into blood during exercise and extravasate afterwards but the magnitude of this response varies between people. We examined whether exercise\u2010induced progenitor cell trafficking is influenced by cardiorespiratory fitness (maximum oxygen uptake; ). Ten males (age: 23\u00a0\u00b1\u00a03\u00a0years; : 61.88\u00a0\u00b1\u00a04.68\u00a0mL\u00a0kg\u00a0min<jats:sup>\u22121<\/jats:sup>) undertook 1\u00a0h of treadmill running at 80% of . Blood samples were collected before exercise (Pre), in the final minute of exercise (0\u00a0h) and afterwards at 0.25, 1 and 24\u00a0h. Pan\u2010progenitor cells (CD34<jats:sup>+<\/jats:sup>, CD34<jats:sup>+<\/jats:sup>CD45<jats:sup>dim<\/jats:sup>) and putative endothelial progenitor cells (CD34<jats:sup>+<\/jats:sup>CD133<jats:sup>+<\/jats:sup>, CD34<jats:sup>+<\/jats:sup>VEGFR2<jats:sup>+<\/jats:sup>, CD34<jats:sup>+<\/jats:sup>CD45<jats:sup>dim<\/jats:sup>VEGFR2<jats:sup>+<\/jats:sup>) were quantified using flow cytometry. Progenitor subpopulations (except for CD34<jats:sup>+<\/jats:sup>CD45<jats:sup>dim<\/jats:sup>VEGFR2<jats:sup>+<\/jats:sup>) increased at 0\u00a0h (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05) and returned to pre\u2010exercise levels by 1\u00a0h.  was positively associated with the exercise\u2010induced progenitor cell response and there were statistically significant time \u00d7  interactions for CD34<jats:sup>+<\/jats:sup>, CD34<jats:sup>+<\/jats:sup>CD45<jats:sup>dim<\/jats:sup> and CD34+CD133<jats:sup>+<\/jats:sup> subpopulations but not VEGFR2\u2010expressing progenitor cells. There were statistically significant correlations between  and <jats:italic>ingress<\/jats:italic> (<jats:italic>r\u00a0<\/jats:italic>&gt;\u00a00.70, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.025) and <jats:italic>egress<\/jats:italic> (<jats:italic>r\u00a0<\/jats:italic>&gt;\u00a0\u22120.77, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.009) of progenitor cell subsets (CD34<jats:sup>+<\/jats:sup>, CD34<jats:sup>+<\/jats:sup>CD45<jats:sup>dim<\/jats:sup>, CD34<jats:sup>+<\/jats:sup>CD133<jats:sup>+<\/jats:sup>), showing that cardiorespiratory fitness influences the magnitude of progenitor cell mobilisation into the blood and subsequent extravasation. These data may provide a link between high levels of cardiorespiratory fitness and vascular health.<\/jats:p>","DOI":"10.1113\/ep092041","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T16:45:58Z","timestamp":1730306758000},"page":"206-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The magnitude of exercise\u2010induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitness"],"prefix":"10.1113","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0204-3915","authenticated-orcid":false,"given":"Mark","family":"Ross","sequence":"first","affiliation":[{"name":"Institue of Life and Earth Sciences Heriot\u2010Watt University  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Aldred","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Drayson","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos A.","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-1430","authenticated-orcid":false,"given":"James E.","family":"Turner","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"ACSM's 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