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The vasodilatory and hypotensive effects of blackberry were investigated through experiments in rat models (<jats:italic>n<\/jats:italic>\u00a0=\u00a05 rats per group) and compared with those of mugwort, which had been demonstrated previously. A nutrigenomic experiment in mouse models (<jats:italic>n<\/jats:italic>\u00a0=\u00a03 mice per group) was also performed for both plants to associate biomarker genes with these effects. Additionally, a phytochemical analysis was carried out to identify the bioactive molecules responsible for the cardiovascular effects. A dose\u2010dependent hypotensive effect and a carbachol\u2010like vasodilatory effect were observed for blackberry and compared with those of mugwort. These effects were associated with the deregulation of gene expression related to vessel lumen expansion (<jats:italic>Amotl2<\/jats:italic>, <jats:italic>Cdh1<\/jats:italic> and <jats:italic>Tfcp2l1<\/jats:italic>) and circulatory system morphology and activity (<jats:italic>Dsp<\/jats:italic>, <jats:italic>Ahnak<\/jats:italic>, <jats:italic>Prcp<\/jats:italic> and <jats:italic>Smtnl2<\/jats:italic>) for both plants. Their functional potential also includes antiproliferative, antimicrobial, anti\u2010inflammatory and appetite\u2010regulating properties. Chlorogenic acids, quercetin and kaempferol derivatives were identified in blackberry as the main bioactive molecules likely to be responsible for its cardiovascular effect. The blackberry extract exhibited a vasorelaxant effect 20 times greater than mugwort, attributed to the exclusive presence of the hypotensive galloyl\u2010<jats:italic>bis<\/jats:italic>\u2010HHDP glucose derivative and a more pronounced upregulation of <jats:italic>Tfcp2l1<\/jats:italic>, which is involved in epithelial cell maturation. This study validates the traditional use of blackberry and mugwort in treatment of hypertension, identifies marker genes and bioactive molecules for vasodilatory and hypotensive effects and expands their potential applications to cancer prevention, inflammation reduction and appetite regulation.<\/jats:p>","DOI":"10.1113\/ep092218","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T01:55:43Z","timestamp":1745546143000},"page":"1217-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nutrigenomic insights and cardiovascular benefits of blackberry (<i>Rubus ulmifolius<\/i> Schott.) and mugwort (<i>Artemisia campestris<\/i> L.)"],"prefix":"10.1113","volume":"110","author":[{"given":"Afaf","family":"Mehiou","sequence":"first","affiliation":[{"name":"Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences University Mohammed First Oujda Morocco"},{"name":"BioEcoAgro Joint Cross\u2010Border Research Unit, UMRt 1158 University of Lille Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9379-6241","authenticated-orcid":false,"given":"Anca","family":"Lucau\u2010Danila","sequence":"additional","affiliation":[{"name":"BioEcoAgro Joint Cross\u2010Border Research Unit, UMRt 1158 University of Lille Lille France"},{"name":"Joint Laboratory CHIC41H, University of Lille\u2010Florimond Desprez Villeneuve d'Ascq France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachee L. 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