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Globally, the number of joint replacement procedures continues to rise annually, with beneficial outcomes in terms of pain relief and quality of life. However, orthopaedic surgery is associated with a transient decline in skeletal muscle mass, strength and function, with resulting impact on balance and posture, mobility and an increased risk of falls during the perioperative period. Perioperative nutrition interventions targeted at mitigating muscle atrophy, strength loss and reduced function in response to orthopaedic surgery have primarily focused on essential amino acid and protein supplementation. Promising results have been observed in patients undergoing total knee arthroplasty, total hip replacement, surgical treatment of hip fracture and anterior cruciate ligament reconstruction. Preliminary evidence also suggests a role for perioperative \u03b2\u2010hydroxy\u2010\u03b2\u2010methylbutyrate supplementation in improving muscle mass and function outcomes following orthopaedic surgery. However, translation of findings from experimental studies into clinical practice is required.<\/jats:p>","DOI":"10.1113\/ep092237","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:21:51Z","timestamp":1746418911000},"page":"1802-1809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Protein\u2010based perioperative nutrition interventions for improving muscle mass and functional outcomes following orthopaedic surgery"],"prefix":"10.1113","volume":"110","author":[{"given":"Oliver C.","family":"Witard","sequence":"first","affiliation":[{"name":"Centre for Human and Applied Physiological Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix K.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Centre for Human and Applied Physiological Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul T.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Sport and Exercise Sciences, Institute of Sport Manchester Metropolitan University Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Larsen","sequence":"additional","affiliation":[{"name":"Arla Foods Ingredients Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip J. 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