{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:13:26Z","timestamp":1788556406654,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is limited knowledge on diffusing capacity in scoliosis patients. It remains to be determined if impaired pulmonary diffusing capacity is mostly influenced by reduced alveolar\u2013capillary membrane diffusing capacity (<jats:italic>D<\/jats:italic><jats:sub>M, CO<\/jats:sub>), reduced pulmonary capillary blood volume (<jats:italic>V<\/jats:italic><jats:sub>C<\/jats:sub>) or both. This study aims to report findings from dual test gas pulmonary diffusing capacity for carbon monoxide and nitric oxide (<jats:italic>D<\/jats:italic><jats:sub>L, CO, NO<\/jats:sub>) with quantification of pulmonary diffusing capacity for carbon monoxide corrected for haemoglobin with a five s breath\u2010hold (<jats:italic>D<\/jats:italic><jats:sub>L, COc, 5s<\/jats:sub>) and nitric oxide with a five s breath\u2010hold (<jats:italic>D<\/jats:italic><jats:sub>L, NO, 5s<\/jats:sub>), <jats:italic>D<\/jats:italic><jats:sub>M, CO<\/jats:sub> and <jats:italic>V<\/jats:italic><jats:sub>C<\/jats:sub>. The study included 57 patients with idiopathic scoliosis seen at our department from 1972 to 1983, all of whom underwent radiological assessment and measurement of <jats:italic>D<\/jats:italic><jats:sub>L, CO, NO<\/jats:sub> during examination 40\u00a0years after diagnosis. One\u2010way ANOVA was performed for between\u2010group differences and Pearson's correlation coefficient was used to assess correlations between <jats:italic>D<\/jats:italic><jats:sub>L, CO, NO<\/jats:sub> metrics and Cobb angle. No significant between\u2010group differences based on disease severity were detected. Thirty\u2010nine percent of the patients were presented with either reduced <jats:italic>D<\/jats:italic><jats:sub>L, COc, 5s<\/jats:sub> or reduced <jats:italic>D<\/jats:italic><jats:sub>L, NO, 5s<\/jats:sub> represented as <jats:italic>Z<\/jats:italic>\u2010scores below \u22121.65. No significant correlations between Cobb angle and <jats:italic>Z<\/jats:italic>\u2010scores for <jats:italic>D<\/jats:italic><jats:sub>L, COc, 5s<\/jats:sub>, <jats:italic>D<\/jats:italic><jats:sub>L, NO, 5s<\/jats:sub>, <jats:italic>D<\/jats:italic><jats:sub>M, CO<\/jats:sub> and <jats:italic>V<\/jats:italic><jats:sub>C<\/jats:sub> according to height measurements were found. When using arm span instead, a weak negative correlation between <jats:italic>D<\/jats:italic><jats:sub>L, COc, 5s<\/jats:sub> and Cobb angle (<jats:italic>r\u00a0<\/jats:italic>=\u00a0\u22120.29; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04) was detected. In conclusion, approximately 39% of patients with idiopathic scoliosis had either reduced <jats:italic>D<\/jats:italic><jats:sub>L, COc, 5s<\/jats:sub> or reduced <jats:italic>D<\/jats:italic><jats:sub>L, NO, 5s<\/jats:sub> 40\u00a0years after diagnosis with varying contributions from <jats:italic>V<\/jats:italic><jats:sub>C<\/jats:sub> or <jats:italic>D<\/jats:italic><jats:sub>M, CO<\/jats:sub>.<\/jats:p>","DOI":"10.1113\/ep092251","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T11:41:06Z","timestamp":1737027666000},"page":"610-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dual test gas pulmonary diffusing capacity in patients with idiopathic scoliosis 40\u00a0years after diagnosis"],"prefix":"10.1113","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3858-3056","authenticated-orcid":false,"given":"Rie S.","family":"Thomsen","sequence":"first","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2227-9375","authenticated-orcid":false,"given":"Milan","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8478-1689","authenticated-orcid":false,"given":"L\u00e6rke C.","family":"Ragborg","sequence":"additional","affiliation":[{"name":"Spine Unit, Department of Orthopaedic Surgery Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-8959","authenticated-orcid":false,"given":"Casper","family":"Dragsted","sequence":"additional","affiliation":[{"name":"Spine Unit, Department of Orthopaedic Surgery Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-9948","authenticated-orcid":false,"given":"S\u00f8ren","family":"Ohrt\u2010Nissen","sequence":"additional","affiliation":[{"name":"Spine Unit, Department of Orthopaedic Surgery Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5523-2763","authenticated-orcid":false,"given":"Martin","family":"Gehrchen","sequence":"additional","affiliation":[{"name":"Spine Unit, Department of Orthopaedic Surgery Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5769-6959","authenticated-orcid":false,"given":"Benny","family":"Dahl","sequence":"additional","affiliation":[{"name":"Spine Unit, Department of Orthopaedic Surgery Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Orthopedics and Scoliosis Surgery Texas Children's Hospital and Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-9506","authenticated-orcid":false,"given":"Ronan M. 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