{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:37:49Z","timestamp":1791351469034,"version":"4.3.1"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Central artery stiffening increases the haemodynamic pulsations transmitted downstream towards target organs, including the brain. While recent evidence suggests that long duration spaceflight is associated with reduced common carotid artery (CCA) distensibility, cerebrovascular pulsatility has not been extensively characterized in astronauts. This study investigated changes in pulsatility from pre\u2010flight to after 6\u00a0months in space, using a secondary analysis of data from four separate experiments. Middle cerebral artery blood velocity (MCAv) was measured during supine rest in 27 astronauts (20 men, 7 women). In subsets of this cohort, we measured CCA distensibility and \u03b2 stiffness (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a020), and CCA wave intensity (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a012). The overall increase in MCAv pulsatility index (PI\n                    <jats:sub>mca<\/jats:sub>\n                    ) from pre\u2010flight to post\u2010flight was not significant (0.73\u00a0\u00b1\u00a00.12 vs. 0.77\u00a0\u00b1\u00a00.11,\n                    <jats:italic>P\u00a0=<\/jats:italic>\n                    \u00a00.060, partial \u03b7\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a00.13). However, individual changes in PI\n                    <jats:sub>mca<\/jats:sub>\n                    were directly associated with changes in estimated aortic pulse pressure (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.51,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.007) and \u03b2 stiffness (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.54,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.015), and inversely associated with changes in distensibility (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.62,\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.003), in separate bivariate analyses. Wave intensity analysis suggested a reduction in normalized wave reflection (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.07), and that forward compression wave amplitude was directly related to PI\n                    <jats:sub>mca<\/jats:sub>\n                    (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.64,\n                    <jats:italic>P =<\/jats:italic>\n                    \u00a00.025). These findings suggest that PI\n                    <jats:sub>mca<\/jats:sub>\n                    in the days immediately following spaceflight is a function of lower carotid distensibility, highlighting the interplay between arterial stiffness and cerebrovascular pulsatility.\n                  <\/jats:p>","DOI":"10.1113\/ep092272","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T12:41:38Z","timestamp":1747658498000},"page":"4235-4247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cerebrovascular pulsatility following long duration spaceflight is associated with changes in pulse pressure and carotid artery stiffness"],"prefix":"10.1113","volume":"111","author":[{"given":"Roxanne","family":"Fournier","sequence":"first","affiliation":[{"name":"Schlegel\u2010UW Research Institute for Aging Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-086X","authenticated-orcid":false,"given":"Danielle K.","family":"Greaves","sequence":"additional","affiliation":[{"name":"Schlegel\u2010UW Research Institute for Aging Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-5979","authenticated-orcid":false,"given":"J. Kevin","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"School of Kinesiology Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Arbeille","sequence":"additional","affiliation":[{"name":"CERCOM\u2010UMPS Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Tours Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-2959","authenticated-orcid":false,"given":"Richard L.","family":"Hughson","sequence":"additional","affiliation":[{"name":"Schlegel\u2010UW Research Institute for Aging Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9095-9877","authenticated-orcid":false,"given":"Andrew D.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Schlegel\u2010UW Research Institute for Aging Waterloo Ontario Canada"},{"name":"Department of Kinesiology and 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