{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:57:19Z","timestamp":1788411439403,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High cardiac sympathetic drive and release of the sympathetic cotransmitter neuropeptide Y (NPY) are significant features of congestive heart failure (CHF), in which resting venous NPY levels are known to be associated with mortality. However, whether circulating NPY levels increase during exercise in CHF when they are already elevated is controversial. We sought to establish the dynamics of circulating NPY levels in CHF patients treated with contemporary medical therapy and devices in relationship to indices of performance linked to long\u2010term prognosis. CHF patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) underwent cardiopulmonary exercise testing with venous blood sampling at rest, peak exercise and recovery. These patients had significantly higher resting venous NPY levels compared with an age\u2010 and sex\u2010matched control group of patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a016) with normal left ventricular function (40\u00a0\u00b1\u00a06.9\u00a0vs. 9.0\u00a0\u00b1\u00a04.6 pg\/mL, respectively; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). In CHF patients, NPY levels increased significantly from baseline to peak exercise (to 93.5\u00a0\u00b1\u00a042.1 pg\/mL; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0004) and remained elevated during recovery (86.8\u00a0\u00b1\u00a044.6 pg\/mL; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0018). The peak (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.58, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0222) and recovery (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.56, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0304) NPY levels and the ability to increase NPY from baseline (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.53, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0427) showed significant positive correlations with heart rate recovery at 1 min, but not with peak oxygen consumption. In CHF patients, the ability to increase NPY levels on exertion is correlated with heart rate recovery, a known prognostic indicator for mortality. These findings suggest that NPY dynamics during exercise might provide valuable insights into sympathetic responses and prognosis in CHF patients.<\/jats:p>","DOI":"10.1113\/ep092325","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T06:38:22Z","timestamp":1737787102000},"page":"401-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Circulating neuropeptide Y dynamics and performance during exercise in heart failure patients with contemporary medical and device therapy"],"prefix":"10.1113","volume":"110","author":[{"given":"Thamali","family":"Ayagama","sequence":"first","affiliation":[{"name":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peregrine G.","family":"Green","sequence":"additional","affiliation":[{"name":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics University of Oxford  Oxford UK"},{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine University of Oxford  Oxford UK"},{"name":"Oxford Heart Centre, John Radcliffe Hospital University of Oxford NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine University of Oxford  Oxford UK"},{"name":"Ludwig Institute for Cancer Research, Nuffield Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Radcliffe Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Holdsworth","sequence":"additional","affiliation":[{"name":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics University of Oxford  Oxford UK"},{"name":"Oxford Heart Centre, John Radcliffe Hospital University of Oxford NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-6133","authenticated-orcid":false,"given":"Neil","family":"Herring","sequence":"additional","affiliation":[{"name":"Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics University of Oxford  Oxford UK"},{"name":"Oxford Heart Centre, John Radcliffe Hospital University of Oxford NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"318","article-title":"Coronary sinus neuropeptide Y levels and adverse outcomes in patients with stable chronic heart failure","volume":"5","author":"Ajijola O. A.","year":"2020","journal-title":"Journal of American Medical Association Cardiology"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.256.1.H132"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.060848"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15515"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP285370"},{"key":"e_1_2_10_7_1","first-page":"VI5","article-title":"Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. The V\u2010HeFT VA Cooperative Studies Group","volume":"87","author":"Cohn J. N.","year":"1993","journal-title":"Circulation"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198409273111303"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910283411804"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303443"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2022.102232"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.024850"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00041.2018"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16120"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-4-808"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31826fb946"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.318458"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.11.016"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0221-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.10.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz115"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/24.2.102"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90150-3"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1990.tb00252.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271588"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz852"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.11.050"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489709113446"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11144-8"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/08037059409102264"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2020.06.002"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90228-3"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.03.022"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3085"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1986.tb00923.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060073"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.15.1510"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312673"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15346"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01652-7"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1994.tb00498.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP285945"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b03505"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP092325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:49:47Z","timestamp":1741747787000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP092325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1113\/EP092325"],"URL":"https:\/\/doi.org\/10.1113\/ep092325","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"assertion":[{"value":"2024-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}