{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:47:34Z","timestamp":1780483654495,"version":"3.54.1"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dynamic resistance exercise (RE) produces sinusoidal fluctuations in blood pressure, with hypotension and cerebral hypoperfusion commonly observed immediately following RE. Whether the cerebral vasculature adapts to these regular blood pressure challenges is unclear. This study examined the cerebrovascular response to post\u2010dynamic RE orthostasis. RE\u2010trained (<jats:italic>n<\/jats:italic>\u00a0=\u00a015, female\u00a0=\u00a04) and healthy untrained individuals (<jats:italic>n<\/jats:italic>\u00a0=\u00a015, female\u00a0=\u00a012) completed five stands: one after seated rest, with each of the subsequent four stands occurring immediately following a set of 10 repetitions of unilateral leg extension exercise at 60% of their one repetition maximum. Beat\u2010to\u2010beat blood pressure, mean middle cerebral artery blood velocity (MCAv<jats:sub>mean<\/jats:sub>) and end\u2010tidal carbon dioxide were measured throughout. During standing the mean arterial blood pressure (MAP) and MCAv<jats:sub>mean<\/jats:sub> nadirs were identified. There was no difference between groups for age (mean\u00a0\u00b1\u00a0SD, 26\u00a0\u00b1\u00a07 RE\u2010trained vs. 25\u00a0\u00b1\u00a06\u00a0years untrained, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.683) or weight (78\u00a0\u00b1\u00a015 vs. 71\u00a0\u00b1\u00a015\u00a0kg, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.683). At MAP nadir during the post\u2010exercise stand, a greater reduction in MAP was observed in the RE\u2010trained group (e.g., set 4, \u221245\u00a0\u00b1\u00a011 vs. \u221236\u00a0\u00b1\u00a06\u00a0mmHg, training effect <jats:italic>P<\/jats:italic>\u00a0=\u00a00.026). However, post\u2010exercise stand MCAv<jats:sub>mean<\/jats:sub> at MCAv<jats:sub>mean<\/jats:sub> nadir was not different (e.g., set 4, \u221220\u00a0\u00b1\u00a07 vs. \u221217\u00a0\u00b1\u00a06\u00a0cm\/s, interaction effect <jats:italic>P<\/jats:italic>\u00a0=\u00a00.478). Rate of regulation was higher in the RE\u2010trained group (set 1, 0.301\u00a0\u00b1\u00a00.170 vs. 0.167\u00a0\u00b1\u00a00.009, training effect <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023). Despite RE\u2010trained individuals demonstrating greater absolute reductions in MAP during orthostasis following RE, there were no differences in MCAv<jats:sub>mean<\/jats:sub>, suggesting that habitual RE may mitigate post\u2010exercise cerebral hypoperfusion.<\/jats:p>","DOI":"10.1113\/ep092327","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T18:19:41Z","timestamp":1735150781000},"page":"424-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Larger reductions in blood pressure during post\u2010exercise standing, but not middle cerebral artery blood velocity, in resistance\u2010trained versus untrained individuals"],"prefix":"10.1113","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5411-1412","authenticated-orcid":false,"given":"Stephanie","family":"Korad","sequence":"first","affiliation":[{"name":"School of Health Sciences Massey University  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4214-8543","authenticated-orcid":false,"given":"Toby","family":"M\u00fcndel","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Nutrition Massey University  Palmerston North New Zealand"},{"name":"Department of Kinesiology Brock University  St Catharines Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-519X","authenticated-orcid":false,"given":"Blake G.","family":"Perry","sequence":"additional","affiliation":[{"name":"School of Health Sciences Massey University  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00035.2017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.91008.2008"},{"key":"e_1_2_9_5_1","first-page":"1081","volume-title":"Transcranial Doppler ultrasound: Valid, invalid, or both?","author":"Ainslie P. N.","year":"2014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/18756557OTc0bOTciTcVY"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.112460"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00790.2016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP091703"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.081687"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/07303084.1993.10606684"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4324\/9780203771587"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)90974-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00823.2020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2014"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13975"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-200211001-00003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00002.2005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.1.245"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00474.2018"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00474.2018"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.168468"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-005-0249-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15287"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP091707"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13984"},{"issue":"02","key":"e_1_2_9_27_1","first-page":"134","article-title":"Hemodynamic responses to blood flow restriction and resistance exercise to muscular failure","volume":"38","author":"Libardi C. A.","year":"2017","journal-title":"International Journal of Sports Medicine"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13428"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.4.1590"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.58.3.785"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.555235"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-198801000-00006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.886655"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2012-090488"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000146380.08401.99"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.857816"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01217.2011"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpy034"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559827610368771"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510008"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-009-1110-x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-018-3948-2"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000002074"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP085449"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP087675"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-019-04291-7"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40798-021-00314-w"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/phy2.233"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3182a7980f"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(02)00108-7"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3180653636"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP090159"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00376653"},{"issue":"2","key":"e_1_2_9_54_1","first-page":"377","article-title":"Exercise and fluid replacement","volume":"39","author":"Sawka M. N.","year":"2009","journal-title":"American College of Sports Medicine Position Stand Exercise and Fluid Replacement"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5967"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.687591"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00151.2023"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00230.2021"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP088743"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.206953"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.13"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16679419"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00651.2014"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.01.011"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.05.058"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP092327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:49:21Z","timestamp":1741747761000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP092327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,25]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1113\/EP092327"],"URL":"https:\/\/doi.org\/10.1113\/ep092327","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,25]]},"assertion":[{"value":"2024-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}