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However, use of \u03b1\u2010agonist vasopressors has been associated with cerebral desaturations. Given that reductions in cerebral oxygen saturation () can increase postoperative neurological dysfunction, we aimed to investigate the impact of noradrenaline (NA) and phenylephrine (PE) on  during the CPB period of a cardiac surgery in 36 patients scheduled for an elective cardiac surgery. Patients were randomized to the intra\u2010operative use of either NA or PE. During CPB, mean arterial pressure (MAP) was elevated pharmacologically to predefined thresholds of 60 and 80\u00a0mmHg, while CPB flow was kept constant. The  values were recorded for 5 min per MAP threshold. The MAP increased adequately between thresholds of 60 and 80\u00a0mmHg (NA, 59\u00a0\u00b1\u00a03\u00a0vs. 81\u00a0\u00b1\u00a03\u00a0mmHg and PE, 61\u00a0\u00b1\u00a04\u00a0vs. 81\u00a0\u00b1\u00a03\u00a0mmHg; <jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a00.01). The  decreased between pressure thresholds of 60 and 80\u00a0mmHg (NA, 70\u00a0\u00b1\u00a011\u00a0vs. 69\u00a0\u00b1\u00a011\u00a0mmHg and PE, 64\u00a0\u00b1\u00a011\u00a0vs. 63\u00a0\u00b1\u00a011\u00a0mmHg; <jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a00.01). Reduction in  did not differ between vasopressors. The mean relative decrease in  across groups was 2.0% (95% confidence interval: 0.6 to 2.1). Elevation in MAP mediated solely by vasopressors induces significant decreases in  during cardiac surgery under CPB. However, their impact on  remains clinically non\u2010significant according to current guidelines.<\/jats:p>","DOI":"10.1113\/ep092387","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T17:38:31Z","timestamp":1737653911000},"page":"798-808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of noradrenaline and phenylephrine on cerebral oxygen saturation during cardiopulmonary bypass in cardiac surgery"],"prefix":"10.1113","volume":"110","author":[{"given":"Edouard","family":"Marques","sequence":"first","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec\u2013Universit\u00e9 Laval  Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne J.","family":"Couture","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec\u2013Universit\u00e9 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