{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T11:04:44Z","timestamp":1756811084478,"version":"3.41.0"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The physiological sequelae of pre\u2010term birth might influence the responses of this population to hypoxia. Moreover, identifying variables associated with development of acute mountain sickness (AMS) remains a key practically significant area of altitude research. We investigated the effects of pre\u2010term birth on nocturnal oxygen saturation () dynamics and assessed the predictive potential of nocturnal \u2010related metrics for morning AMS in 12 healthy adults with gestational age\u00a0&lt;\u00a032\u00a0weeks (pre\u2010term) and 12 term\u2010born control participants. Participants spent one night at a simulated altitude of \u223c4200\u00a0m (normobaric hypoxia; fraction of inspired O<jats:sub>2\u00a0<\/jats:sub>=\u00a00.141), with nocturnal  and heart rate recorded continuously at the fingertip using pulse oximetry and with morning AMS assessed using the Lake Louise scale. Pre\u2010term and term\u2010born participants had similar nocturnal mean  (mean\u00a0\u00b1\u00a0SD; 77%\u00a0\u00b1\u00a03%\u00a0vs. 77%\u00a0\u00b1\u00a04%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.661), minimum  (median[IQR]; 67[4]% vs. 69[5]%; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.223), relative time spent with <jats:sub>\u00a0<\/jats:sub>&lt;\u00a080% (72%\u00a0\u00b1\u00a029%\u00a0vs. 70%\u00a0\u00b1\u00a027%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.879) and mean heart rate (79\u00a0\u00b1\u00a012\u00a0vs. 71\u00a0\u00b1\u00a07\u00a0beats\/min; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.053). However, the increase in  between the two halves of the night was blunted with prematurity (\u22120.12%\u00a0\u00b1\u00a01.51%\u00a0vs. 1.11%\u00a0\u00b1\u00a00.78%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021). Moreover, the cumulative relative desaturation\u2010based hypoxic \u2018load\u2019 was higher with prematurity (32[26]%min\/h vs. 7[25]%min\/h; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.039), underpinned by increased desaturation frequency (69[49] vs. 21[35]\u00a0counts\/h; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). Mean , minimum , morning  and relative time spent with <jats:sub>\u00a0<\/jats:sub>&lt;\u00a080% predicted AMS incidence better than a random classifier exclusively in the pre\u2010term group, with no other variables predictive of AMS in the two groups separately or combined. Overall, pre\u2010term birth might alter nocturnal  dynamics and influence AMS prediction in severe hypoxia.<\/jats:p>","DOI":"10.1113\/ep092418","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T11:41:21Z","timestamp":1737027681000},"page":"821-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nocturnal pulse oxygen saturation dynamics at simulated high altitude: Predictive value for acute mountain sickness in healthy men born pre\u2010term"],"prefix":"10.1113","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7812-5626","authenticated-orcid":false,"given":"Benjamin J.","family":"Narang","sequence":"first","affiliation":[{"name":"Department for Automatics Biocybernetics and Robotics, Jo\u017eef Stefan Institute  Ljubljana Slovenia"},{"name":"Faculty of Sport University of Ljubljana  Ljubljana 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