{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:56:08Z","timestamp":1772160968362,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["789128"],"award-info":[{"award-number":["789128"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nerve regeneration is associated with the plasticity of sensory neurons such that even muscle afferents directed to the skin form mechanosensitive receptive fields appropriate for the new target. STOML3 is an essential mechanotransduction component in many cutaneous mechanoreceptors. Here, we asked whether STOML3 is required for functional and anatomical plasticity following peripheral nerve regeneration. We used a cross\u2010anastomosis model adapted to the mouse, in which the medial gastrocnemius nerve was redirected to innervate hairy skin previously occupied by the sural nerve. We recorded from muscle afferents innervating the skin and found that in wild\u2010type mice their receptive properties were largely identical to normal skin mechanoreceptors. However, in mice lacking STOML3, muscle afferents largely failed to form functional mechanosensitive receptive fields, despite making anatomically appropriate endings in the skin. Our tracing experiments demonstrated that muscle afferents from both wild\u2010type and\n                    <jats:italic>stoml3<\/jats:italic>\n                    mutant mice display remarkable anatomical plasticity, forming new somatotopically appropriate synaptic terminals in the region of the dorsal horn representing the sural nerve territory. The dramatic reduction in stimulus\u2010evoked activity from the cross\u2010anastomosed gastrocnemius nerve in\n                    <jats:italic>stoml3<\/jats:italic>\n                    mutant mice did not prevent central anatomical plasticity. Our results have identified a molecular factor required for functional plasticity following peripheral nerve injury.\n                  <\/jats:p>","DOI":"10.1113\/ep092428","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T16:14:13Z","timestamp":1743524053000},"page":"1473-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The mechanotransduction protein STOML3 is required for proprioceptor plasticity following peripheral nerve regeneration"],"prefix":"10.1113","volume":"110","author":[{"given":"Julia","family":"Haseleu","sequence":"first","affiliation":[{"name":"Department of Neuroscience Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Walcher","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary R.","family":"Lewin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"},{"name":"Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1  Berlin Germany"},{"name":"German Center for Mental Health (DZPG), partner site Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116280"},{"key":"e_1_2_9_3_1","first-page":"683","article-title":"Dehydration and clearing of whole mouse brains and dissected hippocampi for ultramicroscopy","volume":"2013","author":"Becker K.","year":"2013","journal-title":"Cold Spring Harbor protocols"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02185.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00070"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-1305-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012137"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp013001"},{"issue":"1","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/jn.1973.36.1.101","article-title":"Specific regeneration of cutaneous fibers in the cat","volume":"36","author":"Burgess P. 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