{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T20:21:42Z","timestamp":1761164502442,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Central blood volume (CBV) reduction challenges circulatory and respiratory homeostasis, particularly during the initial compensatory phase (0\u20132\u00a0min), when rapid physiological adaptations occur. In this study, we examined dynamic cardiorespiratory responses to CBV reduction using lower\u2010body negative pressure (LBNP) in 11 healthy young males. Participants completed three standardized 2\u00a0min LBNP trials at \u221245\u00a0mmHg, with respiratory variables assessed via flow measurement and breath\u2010by\u2010breath gas analysis, while cardiovascular parameters and cerebral blood flow were monitored using ECG, blood pressure and transcranial Doppler ultrasonography. During LBNP exposure, thoracic admittance, an indicator of CBV reduction, decreased by 13.4% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), indicating significant CBV reduction. Following rigorous statistical correction for multiple comparisons, time\u2010course analysis revealed that mean blood pressure decreased temporarily during the initial phase (0\u201330 s), whereas heart rate increased progressively (16.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). End\u2010tidal  showed a consistent reduction (5.9%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001), whereas minute ventilation and middle cerebral artery mean blood velocity showed no significant changes after statistical correction (\u22129.3% and \u22125.0%, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&gt;\u00a00.05). Exploratory correlation analysis revealed a significant negative correlation between mean blood pressure and tidal volume during the initial phase only (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.78,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.004). Cross\u2010correlation analysis suggested temporal patterns between respiratory and cerebrovascular responses, with respiratory changes preceding cerebrovascular adjustments by 10\u201320\u00a0s. These findings, along with individual variability, suggest rapid cardiorespiratory and cerebrovascular interactions during orthostatic stress, demonstrating dynamic cardiovascular and respiratory responses with distinct temporal patterns that provide insights into physiological mechanisms maintaining homeostasis during gravitational stress.\n                  <\/jats:p>","DOI":"10.1113\/ep092693","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:54:34Z","timestamp":1760115274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time\u2010course analysis of cerebral circulation and cardiorespiratory responses to acute central blood volume reduction in healthy young males"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6610-1891","authenticated-orcid":false,"given":"Marina","family":"Feeley","sequence":"first","affiliation":[{"name":"Graduate School of Human Environment Osaka Sangyo University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Watada","sequence":"additional","affiliation":[{"name":"Faculty of Sport and Health Sciences Osaka Sangyo University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Ito","sequence":"additional","affiliation":[{"name":"Graduate School of Human Environment Osaka Sangyo University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Shimada","sequence":"additional","affiliation":[{"name":"Graduate School of Human Environment Osaka Sangyo University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Sawai","sequence":"additional","affiliation":[{"name":"Faculty of Sport and Health Sciences Osaka Sangyo University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideomi","family":"Nakata","sequence":"additional","affiliation":[{"name":"Graduate School of Human Environment Osaka Sangyo University  Osaka Japan"},{"name":"Faculty of Sport and Health Sciences Osaka Sangyo University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Graduate School of Human Environment Osaka Sangyo University  Osaka Japan"},{"name":"Faculty of Sport and Health Sciences Osaka Sangyo University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5504-6119","authenticated-orcid":false,"given":"Tadayoshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Graduate School of Human Environment Osaka Sangyo University  Osaka Japan"},{"name":"Faculty of Sport and Health Sciences Osaka Sangyo University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.51.5.624"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210000296"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.14326\/abe.13.35"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00006.2018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-002-0630-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00430.2017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.2937"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00128.2013"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10903120801907182"},{"key":"e_1_2_10_12_1","first-page":"231","article-title":"Impedance cardiography: Noninvasive assessment of human central hemodynamics at rest and during exercise","volume":"17","author":"Miles D. S.","year":"1989","journal-title":"Exercise and Sport Sciences Reviews"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00987.2013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1967.213.2.455"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS201200335"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3357\/ASEM.2149.2008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.009817"},{"issue":"4","key":"e_1_2_10_18_1","first-page":"95","article-title":"A gender comparison of cardiovascular responses to lower body negative pressure exposure","volume":"3","author":"Russomano T.","year":"2015","journal-title":"American Journal of Medical and Biological Research"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly188"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00169-7"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP092693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:17:48Z","timestamp":1761070668000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP092693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":19,"alternative-id":["10.1113\/EP092693"],"URL":"https:\/\/doi.org\/10.1113\/ep092693","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"type":"print","value":"0958-0670"},{"type":"electronic","value":"1469-445X"}],"subject":[],"published":{"date-parts":[[2025,10,10]]},"assertion":[{"value":"2025-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"EP092693"}}