{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:59:31Z","timestamp":1786114771968,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A decrease in resting muscle O\n                    <jats:sub>2<\/jats:sub>\n                    uptake () described during bed rest (BR) could determine a decreased whole\u2010body resting energy expenditure (REE), potentially useful during prolonged spaceflights. Two groups of recreationally active men (young [Y],\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a08, age 23\u00a0\u00b1\u00a05\u00a0years; elderly [E],\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a010, age 69\u00a0\u00b1\u00a03\u00a0years) underwent a 21\u2010day (Y) or a 10\u2010day (E) horizontal BR without countermeasures. Measurements were performed before and post\u2010BR. Fat\u2010free mass (FFM) was measured by bioimpedance analysis; REE was measured by open\u2010circuit spirometry; resting  was measured by time\u2010domain near\u2010infrared spectroscopy in the vastus medialis during a transient ischaemia; citrate synthase (CS) activity (estimate of mitochondrial volume) was measured on a vastus lateralis muscle biopsy sample. FFM decreased significantly both in Y (\u22128%,\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001) and in E (\u22125%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.009). Both resting  (\u221245%, \u22122.1% day\n                    <jats:sup>\u22121<\/jats:sup>\n                    in Y,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.025; \u221229%, \u22122.9% day\n                    <jats:sup>\u22121<\/jats:sup>\n                    in E,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.001) and REE (\u221215%, \u22120.7% day\n                    <jats:sup>\u22121<\/jats:sup>\n                    in Y,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.012; \u221212%, \u22121.2% day\n                    <jats:sup>\u22121<\/jats:sup>\n                    in E,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.012) decreased during BR. CS activity decreased in E (\u221231%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.005), whereas the decrease in Y (\u221212%) did not reach statistical significance (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.38). After resting,  data normalized for CS activity values in post\u2010 versus pre\u2010BR were lower in Y (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.021) but not in E (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.99). The decreased resting  and REE may represent a \u2018recalibration\u2019 of ATP supply to a reduced ATP demand, aimed at preventing excessive reactive oxygen species production and muscle atrophy. It would mitigate biological and logistic challenges of prolonged spaceflights, but could negatively impact the health status of the subjects.\n                  <\/jats:p>","DOI":"10.1113\/ep092709","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:40:23Z","timestamp":1775140823000},"page":"2599-2612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bed rest decreases resting skeletal muscle O\n                    <sub>2<\/sub>\n                    uptake and resting energy expenditure in young and elderly subjects"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-9216","authenticated-orcid":false,"given":"Giovanni","family":"Baldassarre","sequence":"first","affiliation":[{"name":"Department of Medicine University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9494-0858","authenticated-orcid":false,"given":"Simone","family":"Porcelli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"},{"name":"Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-4684","authenticated-orcid":false,"given":"Lucrezia","family":"Zuccarelli","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Brocca","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Arboit","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gobbo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Lacerenza","sequence":"additional","affiliation":[{"name":"PIONIRS S.r.l.  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