{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:09:56Z","timestamp":1790834996337,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102022\u201003008"],"award-info":[{"award-number":["RGPIN\u20102022\u201003008"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Topical application of\n                    <jats:sc>l<\/jats:sc>\n                    \u2010menthol, a pharmacological cold\u2010mimetic and agonist of the cold\u2010sensing receptor TRPM8 (transient receptor potential cation channel subfamily M member 8), has been shown to stimulate brown adipose tissue (BAT) thermogenesis and reduce weight gain in both obese and lean male mice, without affecting energy intake. While these findings suggest that\n                    <jats:sc>l<\/jats:sc>\n                    \u2010menthol could offer a novel approach to prevent weight gain, its potential to enhance the benefits of exercise on whole\u2010body metabolic health remains unexplored. In this study, we investigated whether daily topical\n                    <jats:sc>l<\/jats:sc>\n                    \u2010menthol application, combined with voluntary wheel running, could enhance exercise\u2010induced improvements in metabolic health in male and female C57BL\/6J mice housed at thermoneutrality (29\u00b0C). Our results demonstrated that although\n                    <jats:sc>l<\/jats:sc>\n                    \u2010menthol treatment reduced voluntary wheel running distance, there was still a main effect of exercise to reduce fat mass, weight gain and improve glucose tolerance. Indirect calorimetry revealed that\n                    <jats:sc>l<\/jats:sc>\n                    \u2010menthol increased total energy expenditure, potentially explaining improvements in metabolic health despite reductions in voluntary wheel running. These findings suggest that although\n                    <jats:sc>l<\/jats:sc>\n                    \u2010menthol does not enhance the effects of voluntary exercise, it remains a promising strategy for improving metabolic health.\n                  <\/jats:p>","DOI":"10.1113\/ep092754","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T01:39:38Z","timestamp":1749692378000},"page":"111-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Topical application of the cold\u2010mimetic\n                    <scp>l<\/scp>\n                    \u2010menthol decreases wheel running without affecting the beneficial effects of voluntary exercise in mice"],"prefix":"10.1113","volume":"111","author":[{"given":"Annalaura","family":"Bellucci","sequence":"first","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"British 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