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This clinical trial aimed to investigate the effects of an exercise intervention on the metabolome of T2DM participants, fasting and in response to an oral glucose tolerance test (OGTT) and an acute exercise stimulus. Thirteen people with T2DM (age 51\u00a0\u00b1\u00a07 years; body mass index 32.7\u00a0\u00b1\u00a04.9\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) completed 45\u00a0min of moderate\u2010intensity treadmill exercise on 12 days consecutively. Blood samples were collected before and after the first and last training sessions and during a pre\u2010 and postintervention OGTT. Fasted blood samples were collected from 198 healthy control subjects and 208 people with T2DM from an independent cohort for comparison. Samples were analysed using high\u2010resolution\n                    <jats:sup>1<\/jats:sup>\n                    H nuclear magnetic resonance spectroscopy and liquid chromatography\u2013mass spectrometry. The exercise intervention did not induce a shift towards a healthier fasted metabolome in people living with T2DM. In response to consumption of a glucose bolus (OGTT), glycolysis\u2010related metabolites increased and free fatty acids decreased, with no effect of the exercise intervention. In response to acute exercise, glucose and amino acids decreased and free fatty acids increased, with similar responses on the last day of training as on the first day, indicating no effect of the intervention. The clinical trial was registered prospectively in the Australian New Zealand Clinical Trials Registry ACTRN12617000286347 on 24 February 2017.\n                  <\/jats:p>","DOI":"10.1113\/ep092768","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:54:38Z","timestamp":1750726478000},"page":"69-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of short\u2010term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7870-9183","authenticated-orcid":false,"given":"Maartje","family":"Cox","sequence":"first","affiliation":[{"name":"Australian National Phenome Centre, Health Futures Institute, Harry Perkins Institute of Medical Research Murdoch University  Perth Western Australia 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