{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:57:42Z","timestamp":1791493062934,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT\n                    <jats:sub>1<\/jats:sub>\n                    \/MT\n                    <jats:sub>2<\/jats:sub>\n                    ) are prominently expressed in the arcuate nucleus of the hypothalamus \u2013 an essential hub for appetite control \u2013 and in peripheral metabolic tissues where leptin and ghrelin are secreted. Agomelatine, an antidepressant drug and potent MT\n                    <jats:sub>1<\/jats:sub>\n                    \/MT\n                    <jats:sub>2<\/jats:sub>\n                    agonist, offers potential for modulating appetite. This study aimed to investigate the impact of agomelatine on appetite regulation. Forty male Sprague\u2013Dawley rats were randomly allocated into four groups, control (no treatment), vehicle control, agomelatine 20\u00a0mg\/kg (Ago\u201020), and agomelatine 40\u00a0mg\/kg (Ago\u201040), and administered oral gavage for 14\u00a0days. Body weight and food intake were recorded daily. At the end of the experiment, rats were euthanized and blood and hypothalamic tissue samples were obtained. Agomelatine significantly reduced body weight (Ago\u201040: 275.2\u00a0\u00b1\u00a07.2\u00a0g vs. control: 339.7\u00a0\u00b1\u00a08.3\u00a0g,\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.05) and food intake (Ago\u201040: 20.21\u00a0\u00b1\u00a01.32\u00a0g vs. control: 32.09\u00a0\u00b1\u00a01.58\u00a0g,\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.05) by day 14, without affecting water intake. Plasma ghrelin levels decreased (Ago\u201040: 22.54\u00a0\u00b1\u00a03.95\u00a0ng\/dL vs. control: 46.67\u00a0\u00b1\u00a04.84\u00a0ng\/dL,\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.05), while leptin increased (Ago\u201040: 552.30\u00a0\u00b1\u00a041.67\u00a0pg\/mL vs. control: 271.10\u00a0\u00b1\u00a032.12 pg\/mL\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.05). Hypothalamic orexigenic neuropeptides neuropeptide Y (NPY) and agouti\u2010related peptide (AgRP) were suppressed (NPY, Ago40: 0.61\u00a0\u00b1\u00a00.02 vs. Control: 1.36\u00a0\u00b1\u00a00.1321; AgRP, Ago40: 0.52\u00a0\u00b1\u00a00.03 vs. Control: 1.49\u00a0\u00b1\u00a00.27,\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.05), while anorexigenic cocaine\u2010 and amphetamine\u2010regulated transcript (CART) and proopiomelanocortin (POMC) were elevated (CART: Ago40: 1.19\u00a0\u00b1\u00a00.08 vs. Control: 0.92\u00a0\u00b1\u00a00.06; POMC: Ago40: 1.49\u00a0\u00b1\u00a00.17 vs. Control: 0.67\u00a0\u00b1\u00a00.10,\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.05). These findings suggest agomelatine promotes weight loss by modulating appetite\u2010related hormones and hypothalamic neuropeptides, highlighting its potential as a therapeutic for obesity and metabolic disorders.\n                  <\/jats:p>","DOI":"10.1113\/ep092783","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T12:39:03Z","timestamp":1755088743000},"page":"1808-1818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of agomelatine in appetite regulation and body weight in rats"],"prefix":"10.1113","volume":"111","author":[{"given":"Engin","family":"Korkmaz","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Physiology \u0130n\u00f6n\u00fc University  Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"Erden","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Molecular Biology and Genetics Bart\u0131n University  Bart\u0131n T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7i\u011fdem","family":"Tekin","sequence":"additional","affiliation":[{"name":"Vocational School of Health Services, Department of Health Care Services \u0130n\u00f6n\u00fc University  Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2757-1802","authenticated-orcid":false,"given":"Suat","family":"Tekin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physiology \u0130n\u00f6n\u00fc University  Malatya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2008.08.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-023-01324-w"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00328.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2008.00610.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00478.2004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07181"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.65.153"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2022.2123954"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1586\/erc.09.123"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00122"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12580"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2009.00677.x"},{"issue":"9","key":"e_1_2_8_14_1","first-page":"RA217","article-title":"Ghrelin: Central and peripheral effects of a novel peptydil hormone","volume":"9","author":"De Ambrogi M.","year":"2003","journal-title":"Medical Science Monitor"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111399"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.06.004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113445"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.11.009"},{"key":"e_1_2_8_19_1","first-page":"95","article-title":"The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents","volume":"6","author":"Fasipe O. 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