{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:06:26Z","timestamp":1789848386382,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study manipulated the blood pH of participants to be mildly acidic or basic prior to passive hyperthermia to examine its effects on thermoregulatory and chemo\u2010regulatory responses, including ventilatory parameters, rectal temperature (\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>re<\/jats:sub>\n                    ) and thermal perception. Twelve healthy males attended three experimental sessions in a double\u2010blind, randomised, counterbalanced design. Passive hyperthermia was induced by hot water immersion at 40\u00b0C following the consumption of corn starch (placebo; PLA), ammonium chloride (AC) or sodium bicarbonate (SB). Compared with PLA, SB consumption increased blood pH and HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    , whilst AC decreased both blood pH and HCO\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    (all\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001). Specifically, minute ventilation was unchanged following SB (11.0\u00a0\u00b1\u00a03.7\u00a0L\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) but higher following AC (13.2\u00a0\u00b1\u00a05.3\u00a0L\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) compared with PLA (11.9\u00a0\u00b1\u00a05.1\u00a0L\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ;\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a00.002). Changes in ventilatory equivalent for O\n                    <jats:sub>2<\/jats:sub>\n                    and CO\n                    <jats:sub>2<\/jats:sub>\n                    were greater in AC and lower in SB compared with PLA (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.05).\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>re<\/jats:sub>\n                    increased similarly across all conditions (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a00.089), whilst immersion times approached a difference (SB: 51.1\u00a0\u00b1\u00a010.2\u00a0min, AC: 52.9\u00a0\u00b1\u00a08.1\u00a0min, and PLA: 56.8\u00a0\u00b1\u00a06.8\u00a0min;\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a00.06). Thermal sensation was higher in AC compared with PLA and SB (all\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001), with no difference between PLA and SB (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a00.45). Thermal discomfort was not different between AC and SB (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\u00a00.66), both of which were higher than PLA (all\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001). The magnitude and characteristics of ventilatory response during hyperthermia were influenced by prior alkalemia or acidosis, coinciding with differences in thermal perceptions.\n                  <\/jats:p>","DOI":"10.1113\/ep092785","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:15:00Z","timestamp":1773008100000},"page":"2268-2278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of prior alkalosis or acidosis on physiological responses during passive hyperthermia"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6158-2820","authenticated-orcid":false,"given":"Jacky","family":"Soo","sequence":"first","affiliation":[{"name":"Discipline of Exercise Science Murdoch University  Perth Western Australia Australia"},{"name":"Sports Physiology Department, Sport Science and Medicine Centre Singapore Sports Institute  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shernise","family":"Ng","sequence":"additional","affiliation":[{"name":"Sports Physiology Department, Sport Science and Medicine Centre Singapore Sports Institute  Singapore Singapore"},{"name":"Department of Physiology National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Abbiss","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Girard","sequence":"additional","affiliation":[{"name":"School of Human Sciences (Exercise and Sport Science) The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Ihsan","sequence":"additional","affiliation":[{"name":"Physical Education Department, College of Education United Arab Emirates University  Al Ain UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-007-0405-z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00394.2013"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90672.2008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.7.12.8375612"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01375.2010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e31828fd310"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.042143"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00146.2007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1968.25.6.742"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.895ba.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00140137108931266"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.37.1.103"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00010.2010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.2.E316"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00161.2024"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00261.2021"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.5.1558"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apergo.2009.07.007"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.276.1.R32"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200232140-00001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(98)90019-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.212118"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00992.2010a"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3182148a9a"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crphys.2021.06.002"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-014-3027-2"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e3181aeb154"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.36.511"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00232.2017"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2016.1143760"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00335.2012"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13967"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/43.7.673"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00992.2010"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03677-4"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2002.016261"}],"container-title":["Experimental 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