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Here, we report early astrocytic changes in the cerebral cortex following SCI at birth, identified using two specific glial markers in an innovative in vitro model of the entire central nervous system (CNS) isolated from neonatal rats. Immunohistochemical analyses revealed a significant reduction in cortical astrocyte density, first observed in the dorsomedial motor cortex (M1) within 25\u00a0min post\u2010injury, followed by progressive changes in the ventrolateral somatosensory cortex (S1\/S2) at 2\u00a0h post\u2010injury. These findings indicate that SCI initiates a rapid and dynamic reorganization of cortical glial networks, shedding new light on astrocytic responses to spinal trauma.<\/jats:p>","DOI":"10.1113\/ep092809","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:47:00Z","timestamp":1759816020000},"page":"1612-1617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immediate cortical glial alterations following spinal cord injury: Evidence from a novel in vitro model"],"prefix":"10.1113","volume":"111","author":[{"given":"Luca","family":"Mio","sequence":"first","affiliation":[{"name":"Neuroscience Department International School for Advanced Studies (SISSA)  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Pistorio","sequence":"additional","affiliation":[{"name":"Neuroscience Department International School for Advanced Studies (SISSA)  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3734-4427","authenticated-orcid":false,"given":"Atyieh","family":"Mohammadshirazi","sequence":"additional","affiliation":[{"name":"Neuroscience Department International School for Advanced Studies (SISSA)  Trieste Italy"},{"name":"Applied Neurophysiology and Neuropharmacology Lab Istituto di Medicina Fisica e Riabilitazione (IMFR)  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2675-1438","authenticated-orcid":false,"given":"Giuliano","family":"Taccola","sequence":"additional","affiliation":[{"name":"Neuroscience Department International School for Advanced Studies (SISSA)  Trieste Italy"},{"name":"Applied Neurophysiology and Neuropharmacology Lab Istituto di Medicina Fisica e Riabilitazione (IMFR)  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-1171","authenticated-orcid":false,"given":"Carmen","family":"Falcone","sequence":"additional","affiliation":[{"name":"Neuroscience Department International School for Advanced Studies (SISSA)  Trieste Italy"},{"name":"Department of Biological Sciences Towson University  Towson Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0379-10.2010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2022.08.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13982"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102482"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3484"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.04.018"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"386","article-title":"Evaluation of five agents\/methods for anesthesia of neonatal rats","volume":"47","author":"Danneman P. 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