{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:46:38Z","timestamp":1774449998818,"version":"3.50.1"},"reference-count":89,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["413543196"],"award-info":[{"award-number":["413543196"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["390661388"],"award-info":[{"award-number":["390661388"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous and complex, and consequently, the development of pharmacological approaches is lagging behind. On the other hand, dietary interventions, such as caloric restriction, periodic fasting, ketogenic diets and restriction of sulfur\u2010containing amino acids have shown immense potential in preserving kidney function in various rodent models of AKI. Deciphering the underlying, but conserved, molecular mechanisms or renal resilience in mice and humans will help to pave the way to successful transfer to the patient setting and may allow the identification of druggable targets. As these diet\u2010induced protective effects of preconditioning are not limited to the kidney, dietary interventions may even be extended to other tissues like the brain or the heart in the context of AKI and beyond.<\/jats:p>","DOI":"10.1113\/ep092817","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:48:21Z","timestamp":1774446501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-7420","authenticated-orcid":false,"given":"Felix C.","family":"Koehler","sequence":"first","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Department of Internal Medicine (Nephrology) &amp; Einthoven Laboratory of Vascular and Regenerative Medicine Leiden University Medical Center  Leiden Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Rojas\u2010Morales","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6910-0745","authenticated-orcid":false,"given":"Roman\u2010Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Center for Rare Diseases Cologne, Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Department of Nephrology, Medical Faculty University Hospital D\u00fcsseldorf, Heinrich\u2010Heine\u2010University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"issue":"6364","key":"e_1_2_16_2_1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.aan6298","article-title":"Lysosomal metabolomics reveals V\u2010ATPase\u2010 and mTOR\u2010dependent regulation of amino acid efflux from lysosomes","volume":"358","author":"Abu\u2010Remaileh M.","year":"2017","journal-title":"Science"},{"issue":"7","key":"e_1_2_16_3_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.molmed.2024.12.004","article-title":"NAD(+) metabolism in acute kidney injury and chronic kidney disease transition","volume":"31","author":"Alhumaidi R.","year":"2025","journal-title":"Trends in Molecular Medicine"},{"issue":"1","key":"e_1_2_16_4_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1681\/ASN.2015111285","article-title":"Intestinal dysbiosis, barrier dysfunction, and bacterial translocation account for CKD\u2010related systemic inflammation","volume":"28","author":"Andersen K.","year":"2017","journal-title":"Journal of the American Society of Nephrology"},{"issue":"8","key":"e_1_2_16_5_1","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1681\/ASN.2014030288","article-title":"Gut bacteria products prevent AKI induced by ischemia\u2010reperfusion","volume":"26","author":"Andrade\u2010Oliveira V.","year":"2015","journal-title":"Journal of the American Society of Nephrology"},{"issue":"6","key":"e_1_2_16_6_1","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cell.2020.04.027","article-title":"Ketogenic diets alter the gut microbiome resulting in decreased intestinal Th17 cells","volume":"181","author":"Ang Q. 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