{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:24:56Z","timestamp":1790108696815,"version":"4.0.1"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dynamic resistance exercise (RE) produces sinusoidal fluctuations in blood pressure that are mirrored by middle cerebral artery blood velocity (MCAv). However, whether lower\u2010 or upper\u2010body RE elicits a differential cerebrovascular response has not yet been examined. We investigated the cerebrovascular response to lower\u2010body RE versus upper\u2010body RE in 15 healthy untrained individuals (12 females and 3 males; mean\u00a0\u00b1\u00a0SD; age 25\u00a0\u00b1\u00a06 years, height 179\u00a0\u00b1\u00a010\u00a0cm, weight 71\u00a0\u00b1\u00a015\u00a0kg and body mass index 24\u00a0\u00b1\u00a06\u00a0kg\/m<jats:sup>2<\/jats:sup>). Participants completed four sets of 10 paced repetitions (15\u00a0repetitions\/min) of unilateral leg\u2010extension exercise and unilateral bicep\u2010curl exercise at 60% of predicted one\u2010repetition maximum (leg extension 30\u00a0\u00b1\u00a09\u00a0kg and bicep curl 7\u00a0\u00b1\u00a03\u00a0kg). Beat\u2010to\u2010beat blood pressure, bilateral MCAv and partial pressure of end\u2010tidal carbon dioxide were measured throughout. Within\u2010exercise mean arterial blood pressure (MAP) and mean MCAv were averaged across the set. Additionally, zenith, nadir and zenith\u2010to\u2010nadir difference in MAP and mean MCAv for each repetition were averaged across each set. Baseline measures preceding each set were not different for all dependent variables, with no significant interaction differences observed (all <jats:italic>p\u00a0&gt;<\/jats:italic>\u00a00.161). The mean MCAv within exercise decreased across sets (set effect <jats:italic>p\u00a0&lt;<\/jats:italic>\u00a00.001), but MAP did not (<jats:italic>p\u00a0=\u00a0<\/jats:italic>0.071). No interaction effects were observed for any dependent variables (all <jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.06), However, there was a zenith\u2010to\u2010nadir difference in mean MCAv (<jats:italic>p\u00a0=\u00a0<\/jats:italic>0.008), although <jats:italic>post hoc<\/jats:italic> tests revealed no significant difference between exercises (all <jats:italic>p\u00a0&gt;<\/jats:italic>\u00a00.078). There were no differences in the cerebrovascular and cardiovascular responses to lower\u2010 and upper\u2010body RE, with similar sinusoidal fluctuations in MAP and MCAv<jats:sub>mean<\/jats:sub> present during both exercises.<\/jats:p>","DOI":"10.1113\/ep092859","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:55:35Z","timestamp":1759816535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["No difference in mean middle cerebral artery blood velocity responses between lower\u2010 and upper\u2010body unilateral resistance exercise in untrained individuals"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5411-1412","authenticated-orcid":false,"given":"Stephanie","family":"Korad","sequence":"first","affiliation":[{"name":"School of Health Sciences Massey University  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4214-8543","authenticated-orcid":false,"given":"Toby","family":"M\u00fcndel","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Nutrition Massey University  Palmerston North New Zealand"},{"name":"Department of Kinesiology Brock University  St Catharines Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-519X","authenticated-orcid":false,"given":"Blake G.","family":"Perry","sequence":"additional","affiliation":[{"name":"School of Health Sciences Massey University  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1161\/01.STR.20.1.45","article-title":"Cerebral autoregulation dynamics in humans","volume":"20","author":"Aaslid R.","year":"1989","journal-title":"Stroke; A Journal of Cerebral Circulation"},{"issue":"13","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15384","article-title":"Influence of high\u2010intensity interval training to exhaustion on the directional sensitivity of the cerebral pressure\u2010flow relationship in young endurance\u2010trained men","volume":"10","author":"Abbariki F.","year":"2022","journal-title":"Physiological Reports"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1152\/japplphysiol.00854.2014","article-title":"Transcranial Doppler ultrasound: Valid, invalid, or both?","volume":"117","author":"Ainslie P. 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