{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:36:14Z","timestamp":1779107774943,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/ICRF\/24\/26107"],"award-info":[{"award-number":["FS\/ICRF\/24\/26107"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/22\/10937"],"award-info":[{"award-number":["PG\/22\/10937"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The phosphodiesterase\u20105 inhibitor sildenafil suppresses ventricular arrhythmias in a sheep model of drug\u2010induced long QT. In that study, ventricular arrhythmias were abolished by reducing premature ventricular complexes (PVCs) and delaying PVC onset, thus preventing \u2018R\u2010on\u2010T\u2019 ventricular tachycardia. Evidence for effects in humans with arrhythmias is lacking. In this case study, a 50\u2010year\u2010old female with a history of PVCs and systemic sclerosis was started on sildenafil for Raynaud's phenomenon in line with current treatment recommendations. During initiation, the patient wore a 7\u2010day cardiac monitor. Two subtypes of PVCs were observed: one distinct morphology arising &lt;400\u00a0ms from the preceding sinus beat (\u2018early\u2019) and a separate morphology &gt;400\u00a0ms from the preceding sinus beat (\u2018late\u2019). Sildenafil abolished late PVCs and substantially reduced the frequency of early PVCs. Of those early PVCs remaining during sildenafil treatment, PVCs arose later in the cardiac cycle, 21\u00a0ms further from the preceding T wave apex. During washout, PVCs returned in frequency and timing towards baseline values. We report the first case suggesting an anti\u2010arrhythmic property of sildenafil in a human.<\/jats:p>","DOI":"10.1113\/ep092932","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:55:28Z","timestamp":1757544928000},"page":"625-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Suppression of premature ventricular complexes with the PDE5 inhibitor sildenafil: First clinical experience"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5402-8565","authenticated-orcid":false,"given":"David C.","family":"Hutchings","sequence":"first","affiliation":[{"name":"Unit of Cardiac Physiology, Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, 3.24 Core Technology Facility University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Denton","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology, Royal Free Campus, NW3 2PS University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Venetucci","sequence":"additional","affiliation":[{"name":"Unit of Cardiac Physiology, Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, 3.24 Core Technology Facility University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-445X","authenticated-orcid":false,"given":"Andrew W.","family":"Trafford","sequence":"additional","affiliation":[{"name":"Unit of Cardiac Physiology, Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, 3.24 Core Technology Facility University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-309223"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310746"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez434"},{"issue":"6","key":"e_1_2_8_5_1","first-page":"882","article-title":"Primary myocardial disease in scleroderma\u2014A comprehensive review of the literature to inform the UK Systemic Sclerosis Study Group cardiac working group","volume":"56","author":"Bissell L. 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