{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:09:16Z","timestamp":1791086956227,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The contribution of persistent inward currents (PICs) to motoneuron firing in the lower limb typically increases after a remote handgrip contraction, believed to result from diffuse serotonergic input increases in spinal cord. We investigated whether handgrip contraction intensity, duration and\/or impulse would affect PIC estimates in tibialis anterior motoneurons. Multi\u2010channel electromyograms were recorded from the tibialis anterior of 21 participants (18\u201340 years), during dorsiflexions at 20% of the individuals\u2019 maximal torque, before and after four handgrip conditions: (i) 80% of their maximal handgrip strength sustained for 15\u00a0s (80%15s); (ii) 40% sustained for 15\u00a0s (40%15s); (iii) 40% sustained for 30\u00a0s (40%30s); and (iv) no handgrip (Control). The PIC contribution to self\u2010sustained motoneuron firing was estimated with delta frequency (\u0394\n                    <jats:italic>F<\/jats:italic>\n                    ) using paired motor unit analysis. The \u2018brace height\u2019, normalised as a percentage of a right triangle (%\u00a0rTri), was used to estimate the PIC effects on the non\u2010linearity of firing patterns, representing the neuromodulatory drive (metabotropic regulation of motoneuron excitability) onto the motoneurons. \u0394\n                    <jats:italic>F<\/jats:italic>\n                    increased by 0.33 pulses per second (pps; 95% CI: 0.16\u20130.49,\n                    <jats:italic>d\u00a0<\/jats:italic>\n                    =\u00a00.47) after 40%30s and by 0.24\u00a0pps (0.09\u20130.38,\n                    <jats:italic>d\u00a0<\/jats:italic>\n                    =\u00a00.34) after 80%15s, but remained unchanged after 40%15s and Control. Similarly, brace height increased by 2.24% rTri (0.18\u20134.30,\n                    <jats:italic>d\u00a0<\/jats:italic>\n                    =\u00a00.20) after 40%30s and by 2.45% rTri (0.64\u20134.25,\n                    <jats:italic>d\u00a0<\/jats:italic>\n                    =\u00a00.22) after 80%15s, remaining unchanged after 40%15s and Control. The increase in the PIC contribution to motoneuron firing induced by a remote handgrip contraction is impulse dependent rather than intensity or duration dependent. The parallel increases in \u0394\n                    <jats:italic>F<\/jats:italic>\n                    and brace height suggest augmented neuromodulatory input onto the spinal cord.\n                  <\/jats:p>","DOI":"10.1113\/ep092961","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:40:19Z","timestamp":1770165619000},"page":"2200-2213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isometric handgrip contraction increases tibialis anterior intrinsic motoneuron excitability in a dose\u2010dependent manner"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8362-895X","authenticated-orcid":false,"given":"Lucas","family":"Ugliara","sequence":"first","affiliation":[{"name":"Faculty of Physical Education University of Brasilia (UnB)  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-3700","authenticated-orcid":false,"given":"Lucas B. R.","family":"Orssatto","sequence":"additional","affiliation":[{"name":"Centre for Sensorimotor Performance, School of Human Movement and Nutrition Sciences The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6027-4367","authenticated-orcid":false,"given":"Amilton","family":"Vieira","sequence":"additional","affiliation":[{"name":"Faculty of Physical Education University of Brasilia (UnB)  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4667-4257","authenticated-orcid":false,"given":"Gabriel S.","family":"Trajano","sequence":"additional","affiliation":[{"name":"Faculty of Health, School of Exercise and Nutrition Sciences Queensland University of Technology (QUT)  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00194.2020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ac4594"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/acb1d7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016652"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00821.2012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2020.102426"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277396"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011225"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.26.615260"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP286539"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP284164"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP285867"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00277-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00341.2006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ab5eda"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.145078"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858408314986"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.08.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/11\/1\/016008"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/TSP.2007.896108"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1988.sp017336"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.050971"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp013037"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1852"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(02)00187-X"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fncir.2014.00081","article-title":"Gain control mechanisms in spinal motoneurons","volume":"8","author":"Johnson M. 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