{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T15:06:18Z","timestamp":1771081578291,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["143875"],"award-info":[{"award-number":["143875"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013363","name":"Lunge Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We investigated whether nocturnal oxygen therapy improves next\u2010day cerebrovascular function in lowlanders with chronic obstructive pulmonary disease (COPD) staying at moderate altitude. This randomized, placebo\u2010controlled single\u2010blind crossover trial was performed in moderate\u2010to\u2010severe COPD patients [forced expiratory volume in 1\u00a0s (FEV\n                    <jats:sub>1<\/jats:sub>\n                    )\/forced vital capacity (FVC)\u00a0&lt;0.7; FEV\n                    <jats:sub>1<\/jats:sub>\n                    30%\u201380% of predicted], living at\u00a0&lt;800\u00a0m a.s.l. and arterial oxygen saturation () measured with pulse oximetry \u226592%. Patients underwent assessments at 490\u00a0m and during two separate sojourns of 2\u00a0days at 2048\u00a0m, receiving either 3\u00a0L\u00a0min\n                    <jats:sup>\u22121<\/jats:sup>\n                    nocturnal oxygen therapy or placebo in a randomized crossover design. At both altitudes, , cerebral tissue oxygenation (CTO, measured by near\u2010infrared spectroscopy), mean arterial blood pressure (MAP, measured by finger plethysmography) and middle cerebral artery systolic peak blood flow velocity (sMCAv, measured by transcranial Doppler ultrasound) were assessed while patients were quietly breathing with fraction of inspired O\n                    <jats:sub>2<\/jats:sub>\n                    () 0.21, with  1.0, voluntarily hyperventilating, voluntarily hyperventilating with  1.0, and during a head\u2010up tilt. Overall, 18 patients (8 women) aged (mean\u00a0\u00b1\u00a0SD) 65\u00a0\u00b1\u00a05\u00a0years, with FEV\n                    <jats:sub>1<\/jats:sub>\n                    54.7%\u00a0\u00b1\u00a013.9%\u00a0predicted were analysed. At 2048\u00a0m under  0.21, patients became hypoxaemic ( 90.3%\u00a0\u00b1\u00a01.6%), while MAP, CTO and sMCAv remained unchanged compared with 490\u00a0m. All ventilatory manoeuvres at 2048\u00a0m induced greater increases in  compared with 490\u00a0m, while changes in MAP, CTO and sMCAv were similar. Head\u2010up tilt induced a similar decrease in blood pressure, whereas sMCAv changed less in response to systemic hypotension (\u0394sMCAv\/\u0394MAP 0.9\u00a0\u00b1\u00a01.3\u00a0vs. 2.3\u00a0\u00b1\u00a01.7\u00a0cm\u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) at 2048\u00a0m. No effect of nocturnal oxygen therapy was observed during any manoeuvres. This randomized clinical trial in moderate\u2010to\u2010severe COPD patients ascending to 2048\u00a0m showed that moderate hypoxaemia does not translate to daytime cerebral hypoxia or cerebrovascular autoregulatory impairments while at rest or during ventilatory or orthostatic challenges.\n                  <\/jats:p>","DOI":"10.1113\/ep093003","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T23:49:13Z","timestamp":1753228153000},"page":"527-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of moderate altitude and nocturnal oxygen therapy on cerebrovascular function in patients with COPD: A randomized, crossover trial at 2048\u00a0m"],"prefix":"10.1113","volume":"111","author":[{"given":"Dominic","family":"Gilliand","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine University Hospital of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsogyal D.","family":"Latshang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University Hospital of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka S.","family":"Aeschbacher","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University Hospital of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University Hospital of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Flueck","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University Hospital of Zurich  Zurich 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Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University Hospital of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University Hospital of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad E.","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University Hospital of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8518-5029","authenticated-orcid":false,"given":"Michael","family":"Furian","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University Hospital of Zurich  Zurich Switzerland"},{"name":"Research Department Swiss University of Traditional Chinese Medicine  Bad Zurzach Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5438"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.557369"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2023.0053"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.04.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S173039"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13365"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.06.006"},{"issue":"1","key":"e_1_2_10_9_1","article-title":"Acetazolamide to prevent adverse altitude effects in COPD and healthy 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