{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:31:21Z","timestamp":1791747081048,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immediate responses to hypoxia at high altitude are hyperventilation and successive respiratory alkalosis. Alkalosis, in turn, can affect cerebrospinal fluid pH and ventilatory control. The kidneys compensate metabolically for respiratory alkalosis. The time line and detailed sequence of these renal compensatory processes have not been explored thoroughly. We examined the initial adjustments of acid\u2013base and fluid balances during the first 2 days at high altitude.\u00a0 Twelve unacclimatized\u00a0adults of either sex were transported to 3100\u00a0m a.s.l. at the Sonnblick Observatory (Austria). Measurements (fluid and acid\u2013base balance and arterial blood gases) were performed before and 24 and 44\u00a0h after arrival. Exposure to high altitude provoked hyperventilation, resulting in hypocapnia and alkalosis. Altitude diuresis started immediately after arrival at altitude. The only metabolic response within the first 24\u00a0h was a slight reduction in plasma bicarbonate, but after 44\u00a0h distinct reductions in bicarbonate and a trend change in altitude\u2010corrected base excess and arterial pH were observed. Hyperventilation and increased diuresis appeared immediately upon exposure to high\u00a0altitude, whereas compensatory bicarbonate excretion showed the first influence on the arterial pH at the 44\u00a0h measurement. Further research is needed to explore differences in individual responses in the setting of antedated or carry\u2010over acclimatization.<\/jats:p>","DOI":"10.1113\/ep093029","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T17:18:21Z","timestamp":1756142301000},"page":"1387-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early acclimatization to high altitude: Acid\u2013base and fluid balance dynamics during the first 2 days at 3100 m"],"prefix":"10.1113","volume":"111","author":[{"given":"Elisabeth","family":"Skalla","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Medical University of Innsbruck  Innsbruck Austria"},{"name":"Department of Radiology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Treml","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasa","family":"Rajsic","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schreinlechner","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Bukumiri\u0107","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics and Informatics, Faculty of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Berek","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Egger","sequence":"additional","affiliation":[{"name":"Central Institute of Clinical and Chemical Laboratory Diagnostics University Hospital of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Knotzer","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Klinikum Wels  Grieskirchen Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-3632","authenticated-orcid":false,"given":"Martin","family":"Burtscher","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-657X","authenticated-orcid":false,"given":"Axel","family":"Kleinsasser","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/1527029041352108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2008.00827.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2018.0048"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00973.2020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smhs.2021.04.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107646"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.4.665"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2013.01.010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.37.2.247"},{"key":"e_1_2_9_11_1","first-page":"F311","article-title":"Renal carbonic anhydrase","volume":"243","author":"Dobyan D. 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