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This study investigates the vascular roles of T\u2010type VGCCs in the aorta and renal artery of healthy rabbits using functional reactivity assays and immunofluorescence and further elucidates the interaction between T\u2010type VGCC activity and the nitric oxide (NO) signalling pathway. T\u2010type VGCCs contributed to contractile responses induced by phenylephrine and angiotensin II in both arteries. Moreover, in the renal artery, the contribution of T\u2010type VGCCs in response to phenylephrine increased in the absence of NO and was associated with endothelium\u2010dependent vasodilation. Immunofluorescence analysis revealed co\u2010localization of Ca\n                    <jats:sub>V<\/jats:sub>\n                    3.1 with endothelial nitric oxide synthase in the renal artery, but not in the aorta, suggesting a vasodilatory role in renal circulation. These findings highlight vascular bed\u2010specific functions of T\u2010type VGCCs and their interaction with endothelial pathways in the renal artery.\n                  <\/jats:p>","DOI":"10.1113\/ep093044","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:25:52Z","timestamp":1761625552000},"page":"1498-1512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential contribution of T\u2010type voltage\u2010gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0932-7870","authenticated-orcid":false,"given":"Andrea","family":"Suarez","sequence":"first","affiliation":[{"name":"Department of Physiology, InVas and ModulAhR Groups, Facultat de Medicina i Odontologia Universitat de Valencia, INCLIVA Biomedical Research Institute  Valencia 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