{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:06:26Z","timestamp":1789848386458,"version":"4.0.1"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The fetal circulation has unique shunts, including the ductus venosus (DV), the tone of which dictates how much substrate\u2010rich blood returning from the placenta is streamed preferentially away from the liver and instead towards the heart. Herein, we aimed to use clinically relevant MRI techniques in sheep to measure indirectly induced changes in DV tone and the consequences of this on DV shunting, expressed as a ratio of umbilical vein (UV) flow [DV:UV (as a percentage)], and its impact on oxygen delivery to the fetal brain. At 116\u2013117 days gestational age (term\u00a0=\u00a0150 days), fetal sheep (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a011) underwent surgery to implant vascular catheters. Fetal MRI scans were performed at 120\u2013123 days gestational age. Phase contrast MRI and T\n                    <jats:sub>2<\/jats:sub>\n                    MRI oximetry were performed to measure blood flow and oxygen saturation within the fetal circulation during states of fetal normoxaemia, hypoxaemia and hypoxaemia + systemic \u03b1\u2010adrenergic blockade (fetal infusion of the \u03b1\u2010adrenergic antagonist, phentolamine). Hypoxaemia reduced both overall fetal and cerebral oxygen delivery but did not impact either systemic or cerebral oxygen consumption. Fetal hypoxaemia alone did not impact DV shunting. However, addition of \u03b1\u2010adrenergic blockade to acute hypoxaemia significantly decreased DV shunting. Neither fetal hypoxaemia nor the addition of the \u03b1\u2010adrenergic blockade impacted left ventricular cardiac output or blood flow to the brain and the placenta. At the gestational age studied, systemic \u03b1\u2010adrenergic signalling is required to maintain DV shunting during fetal hypoxaemia. However, reduced DV shunting during the systemic \u03b1\u2010adrenergic blockade was not accompanied by a further deficit in cerebral oxygen delivery\n                    <jats:sub>.<\/jats:sub>\n                  <\/jats:p>","DOI":"10.1113\/ep093085","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:00:38Z","timestamp":1771257638000},"page":"1796-1807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u03b1\u2010Adrenergic blockade impairs ductus venosus shunting during an acute period of fetal hypoxaemia without further deficits to cerebral oxygen delivery"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-3920","authenticated-orcid":false,"given":"Jack R. T.","family":"Darby","sequence":"first","affiliation":[{"name":"Early Origins of Adult Health Research Group, Robinson Research Institute, School of Pharmacy and Biomedical Sciences, College of Health Adelaide University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Holman","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Robinson Research Institute, School of Pharmacy and Biomedical Sciences, College of Health Adelaide University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3272-3812","authenticated-orcid":false,"given":"Brahmdeep S.","family":"Saini","sequence":"additional","affiliation":[{"name":"Univeristy of Toronto and The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunthara Rajan","family":"Perumal","sequence":"additional","affiliation":[{"name":"South Australian Health &amp; Medical Research Institute, Preclinical Imaging &amp; Research Laboratories  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7330-234X","authenticated-orcid":false,"given":"Mike","family":"Seed","sequence":"additional","affiliation":[{"name":"Univeristy of Toronto and The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7016-0662","authenticated-orcid":false,"given":"Christopher K.","family":"Macgowan","sequence":"additional","affiliation":[{"name":"Univeristy of Toronto and The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8602-8519","authenticated-orcid":false,"given":"Janna L.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Early Origins of Adult Health Research Group, Robinson Research Institute, School of Pharmacy and Biomedical Sciences, College of Health Adelaide University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1139\/y85-181"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.51.5.580"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(70)90341-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.11.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.5.H1759"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1974.sp010768"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP279054"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3070"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.080523"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1340012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP278110"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280019"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280693"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15749"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1273136"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202100157"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00273.2017"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0383-1"},{"key":"e_1_2_10_20_1","first-page":"H724","article-title":"Preferential streaming of ductus venosus blood to the brain and heart in fetal lambs","volume":"237","author":"Edelstone D. 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