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Preclinically, maternal obesity induced by a high\u2010fat, high\u2010sugar diet (HFHSD) induces hyperphagia and obesity in offspring. We hypothesized that this might, in part, reflect reduced peripheral gastric vagal afferent (GVA) satiety signalling. Female Glu Venus mice were fed a standard laboratory diet (SLD) or HFHSD for 11\u00a0weeks before mating and throughout pregnancy and lactation. Offspring were weaned onto a SLD, then housed in metabolic cages at 6\u20137\u00a0weeks old to assess feeding behaviour. In vitro single\u2010fibre GVA recordings were conducted on tissue collected from 8\u2010week\u2010old mice. Before mating, HFHSD dams were 13% heavier, with 66% higher relative fat mass compared with SLD dams. Maternal diet had no impact on total food intake or offspring weight. Meal size during the light phase was 14% larger in HFHSD than control offspring. Meal duration was longer in HFHSD than control offspring of both sexes across 24\u00a0h and the dark phase, and in females during the light phase. HFHSD offspring ate fewer meals than control offspring across all time periods. Tension\u2010sensitive GVAs responded less to stretch in male, but not female, HFHSD than SLD offspring. Mucosal GVA responses to mucosal stroking were unaffected by maternal diet or offspring sex. In conclusion, exposure in utero and during lactation to elevated maternal adiposity and maternal HFHSD consumption induces male\u2010specific programming of reduced GVA responses to stretch. Meal size was increased in both sexes only during the light phase, suggesting programming of other appetite\u2010regulatory pathways by this exposure.<\/jats:p>","DOI":"10.1113\/ep093108","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:58:26Z","timestamp":1762430306000},"page":"1330-1339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of long\u2010term maternal high\u2010fat, high\u2010sugar feeding on gastric vagal afferent responses and feeding behaviour in mouse offspring"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-6512","authenticated-orcid":false,"given":"Georgia S.","family":"Clarke","sequence":"first","affiliation":[{"name":"School of Biomedicine University of Adelaide  Adelaide SA Australia"},{"name":"Nutrition, Diabetes &amp; Gut Health, Lifelong Health Theme South Australian Health and Medical Research Institute  Adelaide SA Australia"},{"name":"Robinson Research Institute University of Adelaide  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biomedicine University of Adelaide  Adelaide SA Australia"},{"name":"Nutrition, Diabetes &amp; Gut Health, Lifelong Health Theme South Australian Health and Medical Research Institute  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaheh","family":"Heshmati","sequence":"additional","affiliation":[{"name":"School of Biomedicine University of Adelaide  Adelaide SA Australia"},{"name":"Nutrition, Diabetes &amp; Gut Health, Lifelong Health Theme South Australian Health and Medical Research Institute  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly M.","family":"Gembus","sequence":"additional","affiliation":[{"name":"School of Biomedicine University of Adelaide  Adelaide SA Australia"},{"name":"Robinson Research Institute University of Adelaide  Adelaide SA Australia"},{"name":"Adelaide Centre for Epigenetics University of Adelaide  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie E.","family":"O'Hara","sequence":"additional","affiliation":[{"name":"School of Biomedicine University of Adelaide  Adelaide SA Australia"},{"name":"Robinson Research Institute University of Adelaide  Adelaide SA Australia"},{"name":"Adelaide Centre for Epigenetics University of Adelaide  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Nicholas","sequence":"additional","affiliation":[{"name":"School of Biomedicine University of Adelaide  Adelaide SA Australia"},{"name":"Robinson Research Institute University of Adelaide  Adelaide SA Australia"},{"name":"Adelaide Centre for Epigenetics University of Adelaide  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2823-3004","authenticated-orcid":false,"given":"Kathryn L.","family":"Gatford","sequence":"additional","affiliation":[{"name":"School of Biomedicine University of Adelaide  Adelaide SA Australia"},{"name":"Nutrition, Diabetes &amp; Gut Health, Lifelong Health Theme South Australian Health and Medical Research Institute  Adelaide SA Australia"},{"name":"Robinson Research Institute University of Adelaide  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-5865","authenticated-orcid":false,"given":"Amanda J.","family":"Page","sequence":"additional","affiliation":[{"name":"School of Biomedicine University of Adelaide  Adelaide SA Australia"},{"name":"Nutrition, Diabetes &amp; Gut Health, Lifelong Health Theme South Australian Health and Medical Research Institute  Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013442"},{"key":"e_1_2_10_3_1","first-page":"G334","article-title":"Antral control of canine gastric emptying of solids","volume":"245","author":"Becker J. 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