{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:31:58Z","timestamp":1787967118853,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007579","name":"Auburn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effects of high\u2010load (HL) versus high\u2010volume (HV) resistance training (RT) on various molecular outcomes are similar. However, mitochondrial responses remain understudied. Therefore, the purpose of this study was to interrogate mitochondrial mRNA and protein responses to acute and chronic HL versus HV RT. Vastus lateralis biopsies from resistance trained males in two prior studies were assessed. In Study 1, 11 college\u2010aged men completed an acute bout of either HL or HV RT exercises to failure. Biopsies were collected at PRE, 3\u2010h post\u2010, and 6\u2010h post\u2010exercise. In Study 2, 15 college\u2010aged men participated in 6\u00a0weeks of supervised unilateral RT where each leg was assigned to either HL or HV RT. Biopsies were collected from both legs prior to and 72\u00a0h following last training bout of the intervention. Biopsies from both studies were used to assess mitochondrial mRNAs, and Study 2 biopsies were assayed for mitochondrial proteins and citrate synthase (CS) activity. Results from both studies revealed several significant main effects of time but no significant interactions. Additionally, CS activity, a surrogate of mitochondrial content, decreased following chronic RT (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.016) but no interaction was observed between the HV and the HL leg over time (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.882). In conclusion, while RT resulted in both acute mitochondrial mRNA and chronic CS activity and mitochondrial protein responses, there were no differences in the HL versus HV paradigms on these outcomes.\n                  <\/jats:p>","DOI":"10.1113\/ep093172","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:39:46Z","timestamp":1774359586000},"page":"2564-2574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skeletal muscle mitochondrial marker responses to a single bout and 6\u00a0weeks of high load versus high volume resistance training in previously trained men"],"prefix":"10.1113","volume":"111","author":[{"given":"Breanna","family":"Mueller","sequence":"first","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlton D.","family":"Fox","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey A.","family":"Parry","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo H. C.","family":"Mesquita","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Vann","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Ruple","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey L.","family":"Sexton","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Godwin","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mason M.","family":"McIntosh","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren T.","family":"Beck","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"},{"name":"Department of Cell Biology and Physiology Edward Via College of Osteopathic Medicine \u2010 Auburn Campus  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaelin C.","family":"Young","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Pacific Northwest University of Health Sciences  Yakima Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Kinesiology McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas N.","family":"Kavazis","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Roberts","sequence":"additional","affiliation":[{"name":"School of Kinesiology Auburn University  Auburn Alabama USA"},{"name":"Department of Cell Biology and Physiology Edward Via College of Osteopathic Medicine \u2010 Auburn Campus  Auburn Alabama 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