{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:59:28Z","timestamp":1786114768842,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103938"],"award-info":[{"award-number":["82103938"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574195"],"award-info":[{"award-number":["82574195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objective of this work is to assess the effects and potential process of paternal acute sleep deprivation on cardiac function in their offspring. Male and female C57BL\/6N mice aged 8\u20139\u00a0weeks (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a04\u20135 mice\/group) were used. Male mice were selected to construct an acute sleep deprivation model using the modified multiple platform method (MMPM) and mated with normal female mice. After gestation, the weight change of offspring mice was observed and recorded. At the time of 10\u00a0weeks, the changes of cardiac function were evaluated by blood pressure, heart rate and echocardiography; cardiac histology and cytopathological changes were observed by haematoxylin\u2013eosin staining; and the molecular mechanism induced by acute paternal sleep deprivation were further elucidated by molecular biological techniques. In the acute sleep deprivation group, male offspring showed significant cardiac hypertrophy, whereas female offspring did not. mRNA levels of GATA binding protein 4 (GATA4) (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.01) and mRNA levels of classic hypertrophic genes, such as atrial natriuretic peptide (ANP) (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) and brain natriuretic peptide (BNP) (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05), increased significantly in the hearts of the acute sleep deprivation group. Paternal acute sleep deprivation may lead to cardiac dysfunction in offspring through cardiac hypertrophy.\n                  <\/jats:p>","DOI":"10.1113\/ep093212","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:07:13Z","timestamp":1775754433000},"page":"2518-2527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paternal sleep deprivation and cardiac dysfunction in offspring: A perspective of myocardial hypertrophy"],"prefix":"10.1113","volume":"111","author":[{"given":"Yingying","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Pan","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zou","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlin","family":"Bai","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiling","family":"Fang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanbao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Occupational Safety and Health, Institute of Urban Safety and Environmental Science Beijing Academy of Science and Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijian","family":"Lei","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9314-7460","authenticated-orcid":false,"given":"Wenping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-015-4212-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.08.014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.10.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-024-00525-x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2017.12.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/736860"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.073181"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00747-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg5159"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes7020006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16010012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2018.02.019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80196-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.10.014"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleh.2020.01.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa110"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12865"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.179291"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2014.05.057"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20105"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8770136"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.027557"},{"issue":"591729","key":"e_1_2_8_24_1","article-title":"The impact of sleep and circadian disturbance on hormones and metabolism","volume":"2015","author":"Kim T. W.","year":"2015","journal-title":"International Journal of Endocrinology"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.07.048"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113075"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.12.006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2015.08.016"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-387786-4.00008-7"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-022-02974-3"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15841"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-022-00880-z"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.12.114"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2006.08.005"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000535784"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSMBR.900437"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31655-z"},{"key":"e_1_2_8_38_1","first-page":"103","article-title":"Effects of acute and chronic sleep deprivation on cardiovascular regulation","volume":"152","author":"Tobaldini E.","year":"2014","journal-title":"Archives Italiennes De Biologie"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095-8137.2022.023"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12863"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-018-2166-3"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115280"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.3018"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP093212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T21:37:38Z","timestamp":1785965858000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP093212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1113\/EP093212"],"URL":"https:\/\/doi.org\/10.1113\/ep093212","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]},"assertion":[{"value":"2025-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}