{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:47:03Z","timestamp":1773010023131,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Established methods of measuring functional residual capacity (FRC) involve sophisticated equipment and elaborate procedures. Here we present a new method based on CO\n                    <jats:sub>2<\/jats:sub>\n                    rebreathing that has a simple fast procedure and only requires end\u2010tidal CO\n                    <jats:sub>2<\/jats:sub>\n                    monitoring. Ten healthy subjects with diverse anthropometric and respiratory parameters were studied in the sitting position. Reference FRC (RefFRC) and tidal volume (TV) were measured with a Cosmed Quark PFT\/DLCO unit using the single\u2010breath methane dilution technique in combination with spirometry. Rebreathing through an external dead space of precisely known volume and recording the rising end\u2010tidal CO\n                    <jats:sub>2<\/jats:sub>\n                    value of the first two breaths allows the determination of effective lung volume (ELV) and the calculation of FRC. Two sets of measurements were made on each subject 15\u00a0min apart. Bland\u2013Altman analysis of a comparison between FRC and RefFRC showed a mean bias of 0.04\u00a0L, with limits of agreement (LoA, 95% CI) of \u22121.24 to +1.32\u00a0L and a percentage error (PE)\u00a0of 0.54. When the mean value of two observations from a subject (meanFRC) was compared to RefFRC we obtained a mean bias of \u22120.08\u00a0L, LoA (95% CI) of \u20130.88 to +0.72\u00a0L and PE of 0.23. The FRC data obtained demonstrate good absolute accuracy. An average of repeated measurements improves precision indicating that a criterion for exchangeability with the reference method can be met. The simplicity of the equipment and the procedure could make this method attractive in the pre\u2010operative and the post\u2010operative settings, as well as in out\u2010of\u2010hospital applications.\n                  <\/jats:p>","DOI":"10.1113\/ep093229","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T03:27:45Z","timestamp":1760412465000},"page":"620-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A new method for bedside determination of effective lung volume and functional residual capacity"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4519-8948","authenticated-orcid":false,"given":"Andras","family":"Gedeon","sequence":"first","affiliation":[{"name":"Mincor AB  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Jansson","sequence":"additional","affiliation":[{"name":"Spirotronic AB  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Patrickson","sequence":"additional","affiliation":[{"name":"eHeart AB  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-0089","authenticated-orcid":false,"given":"Mats","family":"Wallin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.37.9.676"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01519-2022"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-011-9318-9"},{"key":"e_1_2_9_6_1","first-page":"893","article-title":"Reference values for pulmonary tissue volume, membrane diffusing capacity, and pulmonary. capillary blood volume","volume":"18","author":"Crapo R. O.","year":"1982","journal-title":"Bulletin Europ\u00e9en de Physiopathologie Respiratoire"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009982611386"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.suppl_2.58S"},{"key":"e_1_2_9_9_1","unstructured":"Gedeon A.(2023).Swedish Patent SE 545548."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105846"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-021-00236-w"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/dtb.2023.000026"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/20018525.2024.2381898"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930089"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.01040.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00069712"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04928-w"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP093229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:04:15Z","timestamp":1773003855000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP093229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1113\/EP093229"],"URL":"https:\/\/doi.org\/10.1113\/ep093229","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]},"assertion":[{"value":"2025-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}