{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:07:29Z","timestamp":1789848449835,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Consumption of a high\u2010sugar mixed meal (HSMM) increases both glucose and insulin and elicits mixed vascular effects, with reduced microvascular blood flow but increased conduit artery diameter and blood flow. In this study, we sought to examine: (1) whether an HSMM elicits vascular segment\u2010specific effects within cerebrovasculature; and (2) whether these responses differ between young healthy adults and middle\u2010aged adults with cardiometabolic disease (CMD) risk factors. Twenty\u2010one young, healthy adults (ages 18\u201339 years; 24\u00a0\u00b1\u00a06 years) and 20 middle\u2010aged adults (ages 40\u201365 years; 55\u00a0\u00b1\u00a05 years) with CMD risk factors (hypertension, obesity or dyslipidaemia) underwent cerebrovascular assessments before and at 30 and 60\u00a0min after a 930 kcal HSMM. Carotid and aortic stiffness and carotid artery characteristic impedance were assessed via ultrasound and tonometry. Middle cerebral artery mean velocity, pulsatility index and resistive index were assessed via transcranial Doppler. In comparison to baseline, common carotid artery diameter increased while stiffness decreased, contributing to a decrease in carotid artery characteristic impedance in both groups following the HSMM (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). In comparison to baseline, middle cerebral artery mean velocity, pulsatility index and resistive index increased only in young adults (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) following the HSMM. Differential increases in cerebral pulsatility among young adults compared with middle\u2010aged adults with CMD risk factors might reflect modest differences in upstream, extracranial artery pulsatile transmission following an HSMM, along with simultaneous, complex intracranial cerebrovascular responses that require further interrogation. Cumulatively, these data suggest that: (1) the cerebrovascular response to an HSMM might differ between segments of the extra\u2010 versus intracranial cerebrovasculature; and (2) middle\u2010aged adults with CMD risk factors might have altered cerebrovascular responsiveness to an HSMM compared with young, healthy adults.\n                  <\/jats:p>","DOI":"10.1113\/ep093238","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T15:28:30Z","timestamp":1763825310000},"page":"2370-2383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of a high\u2010sugar mixed meal on cerebrovascular haemodynamics in young, healthy versus middle\u2010aged adults with cardiometabolic risk factors"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7253-0114","authenticated-orcid":false,"given":"Krista S.","family":"Reed","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health Iowa State University  Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly R.","family":"Crew","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Iowa State University  Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby M.","family":"Frescoln","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Iowa State University  Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer M.","family":"Romanowski","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Iowa State University  Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy J.","family":"Valentine","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Kinesiology University of Massachusetts Lowell  Lowell Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5957-391X","authenticated-orcid":false,"given":"Wesley K.","family":"Lefferts","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Iowa State University  Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,22]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Alzheimer's disease facts and figures","author":"Alzheimer's 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