{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:46:28Z","timestamp":1773009988495,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS099188"],"award-info":[{"award-number":["R01NS099188"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS129643"],"award-info":[{"award-number":["R01NS129643"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL172970"],"award-info":[{"award-number":["R01HL172970"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL145753"],"award-info":[{"award-number":["R01HL145753"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL145753\u201001S1"],"award-info":[{"award-number":["R01HL145753\u201001S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL145753\u201003S1"],"award-info":[{"award-number":["R01HL145753\u201003S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The leading cause of epilepsy\u2010related mortality is sudden unexpected death in epilepsy (SUDEP), resulting from seizure\u2010induced cardiorespiratory arrest by mechanisms that remain unresolved. Mutations in ion channel genes expressed in both brain and heart represent SUDEP risk factors because they can disrupt neural and cardiac rhythms, providing a unified explanation for seizures and lethal arrhythmias. However, the relative contributions of brain\u2010driven mechanisms, heart\u2010intrinsic processes and seizures to cardiac dysfunction in epilepsy remain unclear. Here, we investigated the heart\u2010specific role of the\n                    <jats:italic>Kcna1<\/jats:italic>\n                    gene, which encodes Kv1.1 voltage\u2010gated potassium channel \u03b1\u2010subunits expressed in both neurons and cardiomyocytes, where they shape action potential firing and influence seizure and arrhythmia susceptibility. We generated cardiac\u2010specific\n                    <jats:italic>Kcna1<\/jats:italic>\n                    conditional knockout (cKO) mice lacking Kv1.1 selectively in cardiomyocytes and assessed their cardiac function using in vitro and in vivo electrophysiology. Cardiac Kv1.1 deficiency prolonged action potentials in atrial, but not ventricular, cardiomyocytes, demonstrating a direct role for Kv1.1 in atrial repolarization. Despite these cellular effects, cKO mice exhibited normal lifespans, electrocardiographic features, heart rate variability, pacing\u2010induced arrhythmia susceptibility, contractility, seizure susceptibility and seizure\u2010induced mortality. Thus, while loss of cardiac Kv1.1 was sufficient to impair atrial repolarization, it did not reproduce the broader cardiac abnormalities seen in global\n                    <jats:italic>Kcna1<\/jats:italic>\n                    knockouts. Given the higher mortality rates of global compared with neural\u2010specific knockouts in our previous studies, cardiac Kv1.1 deficiency, while not lethal alone, may increase vulnerability to seizure\u2010related death when combined with neural deficiency, consistent with a brain\u2013heart dyssynergy that lowers the threshold for fatal events.\n                  <\/jats:p>","DOI":"10.1113\/ep093249","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T12:46:36Z","timestamp":1763210796000},"page":"1120-1133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac\u2010specific Kv1.1 deficiency alters cardiomyocyte electrophysiology without modifying overall cardiac function or arrhythmia susceptibility"],"prefix":"10.1113","volume":"111","author":[{"given":"Kelsey","family":"Halvorson","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Southern Methodist University  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Southern Methodist University  Dallas Texas USA"},{"name":"Department of Cellular Biology and Anatomy Louisiana State University Health Sciences Center  Shreveport Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystle","family":"Trosclair","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy Louisiana State University Health Sciences Center  Shreveport Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Aughenbaugh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Southern Methodist University  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6629-1974","authenticated-orcid":false,"given":"Maxine","family":"Parkinson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Southern Methodist University  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Gautier\u2010Hall","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology and Anatomy Louisiana State University Health Sciences Center  Shreveport Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Watts","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Cardiology Louisiana State University Health Sciences Center  Shreveport Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederica","family":"Kizek","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Southern Methodist University  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. 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