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Here, we examined a novel class of signalling molecules, mitochondrial\u2010derived microproteins (MDPs), and assessed whether individuals with CP exhibit altered circulating levels compared with typically developing (TD) individuals at rest and following an acute bout of endurance exercise. Three groups were included: TD adults (31\u00a0\u00b1\u00a06\u00a0years), TD adolescents (16\u00a0\u00b1\u00a01\u00a0years) and adults with CP (25\u00a0\u00b1\u00a06\u00a0years). Individuals with CP were classified as Gross Motor Function Classification System (GMFCS) levels II\u2212IV and had at least 3\u00a0months of frame running experience. Habitual physical activity, ultrasound\u2010derived muscle thickness, and peak oxygen uptake were assessed. The exercise session consisted of 45\u00a0min of frame running for individuals with CP and conventional running for TD participants. Blood samples were obtained before and 1\u00a0h after exercise, and plasma MDP concentrations were measured using in\u2010house enzyme\u2010linked immunosorbent assay. Adults with CP had reduced muscle mass and maximal oxygen uptake compared to TD individuals. Despite this, they exhibited basal circulating levels of MDPs, including humanin, MOTS\u2010c and SHMOOSE, comparable to TD adults and adolescents, with no associations with CP subtype or motor impairment severity. Following exercise, circulating MDPs showed no or only modest changes across groups, with no differences between CP and TD individuals. Overall, these findings suggest preserved mitochondrial\u2010derived signalling via MDPs in individuals with CP.<\/jats:p>","DOI":"10.1113\/ep093298","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:11:41Z","timestamp":1782432701000},"page":"3772-3783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating mitochondrial\u2010derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3500-2896","authenticated-orcid":false,"given":"Oscar","family":"Horwath","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology, Department of Women's and Children's Health Karolinska Institute  Stockholm Sweden"},{"name":"Department of Physiology, Nutrition and Biomechanics The Swedish School of Sport and Health Sciences  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