{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T21:17:55Z","timestamp":1779225475927,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anorexia nervosa (AN) is a psychiatric disorder characterized by prolonged caloric restriction and skeletal muscle atrophy. Mitochondrial health is a key mediator of muscle function, yet the role of mitochondria during AN and following weight regain has not been investigated. The objective of this study was to evaluate mitochondrial capacities and quality control mechanisms in a rodent model of AN, spanning the acute underweight phase and multiple recovery periods. Through a series of experiments, 8\u2010week\u2010old female Sprague\u2013Dawley rats underwent a 30\u2010day simulated AN protocol, followed by different durations of weight recovery via ad libitum feeding. Following designated interventions, muscle performance on a submaximal fatiguing protocol and components of mitochondrial function were evaluated. AN resulted in 23%\u201325% lower muscle performance compared to healthy controls, and these alterations remained even after short\u2010term weight gain. AN rats had 23% lower contribution of complex I to maximal mitochondrial electron transfer as well as alterations to genes important for mitochondrial translation and dynamics, many of which were not resolved with short\u2010term recovery. With long\u2010term recovery, muscle performance and mRNA content of genes related to mitochondrial translation were similar to healthy controls. However, genes related to mitochondrial fission were greater than healthy controls. AN results in reduced muscle performance during a fatiguing protocol, reliance on mitochondrial complex I and genes related to mitochondrial quality control. Many alterations persist with short\u2010term weight recovery; however, given sufficient time, many facets of mitochondrial health appear to normalize following AN, though there still may be long\u2010term consequences to mitochondrial dynamics.<\/jats:p>","DOI":"10.1113\/ep093325","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T10:26:16Z","timestamp":1764411976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mitochondrial capacities and quality control following short\u2010 and long\u2010term weight restoration after simulated anorexia nervosa"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-1021","authenticated-orcid":false,"given":"Megan E.","family":"Rosa\u2010Caldwell","sequence":"first","affiliation":[{"name":"Energy Availability and Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Health Human Performance and Recreation University of Arkansas  Fayetteville Arkansas USA"},{"name":"Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby L.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Molecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health Human Performance and Recreation University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Breithaupt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Harvard Medical School, Eating Disorders Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Mass General Brigham Multidisciplinary Eating Disorders Research Collaborative Mass General Brigham  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruqaiza","family":"Muhyudin","sequence":"additional","affiliation":[{"name":"Cachexia Research Laboratory, Exercise Science Research Center, Department of Health Human Performance and Recreation University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patience Salvalina","family":"Okoto","sequence":"additional","affiliation":[{"name":"Arkansas Integrative Metabolic Research Center University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadie R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Energy Availability and Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Health Human Performance and Recreation University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily E.","family":"Rothacker","sequence":"additional","affiliation":[{"name":"Energy Availability and Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Health Human Performance and Recreation University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Greenhill","sequence":"additional","affiliation":[{"name":"Energy Availability and Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Health Human Performance and Recreation University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie A.","family":"Wood","sequence":"additional","affiliation":[{"name":"Energy Availability and Muscle Metabolism Laboratory, Exercise Science Research Center, Department of Health Human Performance and Recreation University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin A.","family":"Murach","sequence":"additional","affiliation":[{"name":"Molecular Muscle Mass Regulation Laboratory, Exercise Science Research Center, Department of Health Human Performance and Recreation University of Arkansas  Fayetteville Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah H.","family":"White\u2010Springer","sequence":"additional","affiliation":[{"name":"Equine Physiology, Department of Animal Science, College of Agriculture and Life Sciences; Department of Kinesiology &amp; Sport Management, School of Education and Human Development Texas A&amp;M University  College Station Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula B.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Hypertension Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6375-3312","authenticated-orcid":false,"given":"Seward B.","family":"Rutkove","sequence":"additional","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"issue":"7","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/archgenpsychiatry.2011.74","article-title":"Mortality rates in patients with anorexia nervosa and other eating disorders. 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