{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:06:27Z","timestamp":1789848387926,"version":"4.0.1"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015306","name":"Brain Health Institute, Rutgers, The State University of New Jersey","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100015306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK133598\u201001A1"],"award-info":[{"award-number":["R01DK133598\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Reductions in brain insulin sensitivity and cerebral blood flow (CBF) have emerged as potential factors contributing to Alzheimer's disease and related dementia. However, no work has tested whether a single bout of exercise can raise brain insulin sensitivity in at\u2010risk adults. The aim of the study was to test whether a single bout of exercise raises brain insulin sensitivity in middle\u2010aged to older adults with cardiometabolic risk. In a counterbalanced pilot study design, 15 cognitively unimpaired (Montreal Cognitive Assessment, 28.2\u00a0\u00b1\u00a01.3 a.u.) adults [56.7\u00a0\u00b1\u00a02.1\u00a0years old; maximal oxygen consumption (), 23.9\u00a0\u00b1\u00a00.9\u00a0mL\/kg\/min] with excess body weight (body mass index, 31.8\u00a0\u00b1\u00a01.3\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) and impaired glucose tolerance (haemoglobin A1c, 5.8%\u00a0\u00b1\u00a00.30%) were randomized to a rest (time\u2010matched control) or acute treadmill exercise bout (70%  for 60 min) in the evening. The next morning, participants arrived fasted to determine brain insulin sensitivity. Plasma glucose and insulin, in addition to CBF, were assessed by pseudo\u2010continuous arterial spin labelling before and after intranasal insulin (40 IU). Cognition (NIH toolbox), aerobic fitness () and body composition (dual\u2010energy X\u2010ray absorptiometry) were also analysed. There was no difference in plasma glucose or insulin following intranasal with or without exercise. Although cognition was also not improved, exercise increased CBF in the hippocampus, putamen and pallidum (condition effect,\u00a0\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u00a00.05). Exercise\u2010induced increases in fasting hippocampus, caudate, pallidum and putamen CBF were correlated with a lowering of CBF responses to insulin. In middle\u2010aged to older adults with cardiometabolic risk, a single bout of exercise increased fasting CBF, and this related to decreased CBF insulin responses in regions related to memory and motor control.\n                  <\/jats:p>","DOI":"10.1113\/ep093333","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:43:14Z","timestamp":1766580194000},"page":"1948-1959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of a single exercise bout on fasting cerebral blood flow and brain insulin sensitivity in middle\u2010aged to older adults"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7360-6711","authenticated-orcid":false,"given":"Steven K.","family":"Malin","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health Rutgers University  New Brunswick New Jersey USA"},{"name":"Department of Medicine, Division of Endocrinology, Metabolism and Nutrition Rutgers University  New Brunswick New Jersey USA"},{"name":"New Jersey Institute for Food, Nutrition and Health Rutgers University  New Brunswick New Jersey USA"},{"name":"Institute of Translational Medicine and Science Rutgers University  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism and Nutrition Rutgers University  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal S.","family":"Berri","sequence":"additional","affiliation":[{"name":"Institute for Health, Health Care Policy and Aging Research Rutgers University  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Zald","sequence":"additional","affiliation":[{"name":"Center for Advanced Human Brain Imaging Research Rutgers University  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Battillo","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Rutgers University  New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01458-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101192"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.185"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.12.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14982"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00866.2021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14497"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14070878"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01303-9"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2022.12.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1722"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000624"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050068"},{"issue":"10","key":"e_1_2_10_15_1","first-page":"1246","article-title":"Associations between midlife vascular risk factors and 25\u2010year incident dementia in the atherosclerosis risk in communities (ARIC) Cohort","volume":"74","author":"Gottesman R. 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