{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:25:19Z","timestamp":1786119919530,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004960","name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004960","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008688","name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We investigated whether higher body mass index (BMI) modifies time\u2010resolved maternal autonomic control and maternal cardio\u2010electrohysterographic coupling (MCEC) during the first stage of labour. Seventy\u2010nine women were studied and, for the present analysis, grouped as Control (C;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a041) and high BMI (HBMI;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a038). Maternal inter\u2010beat intervals were used to derive time\u2010resolved cardiac sympathetic (CSI) and cardiac vagal (CVI) indices, while uterine activity was obtained from electrohysterography. Compared with controls, HBMI showed higher median CSI and CVI and higher uterine irregularity, consistent with overall autonomic overactivation (increased sympathetic and vagal\u2010related modulation) as captured by these indices. Phase\u2010based coupling analyses indicated a shift in vagal\u2010related phase timing that correlated with BMI as a continuous variable, suggesting that altered MCEC was primarily expressed as a shift in vagal\u2013uterine phase timing. Overall, higher BMI was associated with altered maternal autonomic dynamics and vagal\u2013uterine timing during labour. These findings support BMI\u2010aware, non\u2010invasive intrapartum monitoring as a potential approach to improve physiological interpretation and help guide more individualized labour management.\n                  <\/jats:p>","DOI":"10.1113\/ep093339","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T01:09:18Z","timestamp":1777165758000},"page":"3203-3215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Higher body\u2010mass index modifies time\u2010resolved maternal autonomic cardiac\u2013uterine coupling during the first stage of human labour"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6389-0348","authenticated-orcid":false,"given":"Carlos Gabriel","family":"Varela\u2010Albarr\u00e1n","sequence":"first","affiliation":[{"name":"School of Medicine Autonomous University of the State of Mexico (UAEM\u00e9x)  Toluca de Lerdo Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5361-5007","authenticated-orcid":false,"given":"Jos\u00e9 Javier","family":"Reyes\u2010Lagos","sequence":"additional","affiliation":[{"name":"Bioelectronics Section Electrical Engineering Department Center for Research and Advanced Studies Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2171-518X","authenticated-orcid":false,"given":"Laura Mercedes","family":"Santiago\u2010Fuentes","sequence":"additional","affiliation":[{"name":"School of Medicine Autonomous University of the State of Mexico (UAEM\u00e9x)  Toluca de Lerdo Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0649-6185","authenticated-orcid":false,"given":"Guadalupe","family":"Dorantes\u2010M\u00e9ndez","sequence":"additional","affiliation":[{"name":"School of Sciences Autonomous University of San Luis Potos\u00ed (UASLP)  San Luis Potos\u00ed Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-3790","authenticated-orcid":false,"given":"Eric Alonso","family":"Abarca\u2010Castro","sequence":"additional","affiliation":[{"name":"Division of Biological and Health Sciences Autonomous Metropolitan University Lerma Campus (UAM\u2010L) Lerma de Villada Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0787-6678","authenticated-orcid":false,"given":"Paula Romina","family":"Soria","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Institute of Biomedical Engineering University of Buenos Aires  Buenos Aires Argentina"},{"name":"Argentine Institute of Mathematics \u2018Alberto P. Calder\u00f3n\u2019 CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8116-6558","authenticated-orcid":false,"given":"Araceli","family":"Espinosa\u2010Guerrero","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Hospital Maternal and Child Institute of the State of Mexico (IMIEM) Toluca de Lerdo Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/ac84c0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genm.2012.02.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAFFC.2025.3548778"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP288400"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP092532"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.240750"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","unstructured":"Esquivel\u2010Arizmendi C. G. Ledesma\u2010Ram\u00edrez C. I. Pliego\u2010Carillo A. C. Echeverr\u00eda J. C. Pe\u00f1a\u2010Castillo M. \u00c1. Pacheco\u2010L\u00f3pez G. &Reyes\u2010Lagos J. J.(2020).Analysis of the maternal cardio\u2010electrohysterographic coupling during labor by bivariate phase\u2010rectified signal averaging. InIFMBE proceedings(pp.21\u201327).Springer.https:\/\/doi.org\/10.1007\/978\u20103\u2010030\u201030648\u20109_3","DOI":"10.1007\/978-3-030-30648-9_3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0283116"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1332"},{"key":"e_1_2_9_11_1","first-page":"429","article-title":"Theory of communication. Part 1: The analysis of information","volume":"93","author":"Gabor D.","year":"1946","journal-title":"Journal of the Institution of Electrical Engineers\u2014Part III: Radio and Communication Engineering"},{"key":"e_1_2_9_12_1","unstructured":"Gobierno de M\u00e9xico. (2024).Informes semanales para la vigilancia epidemiol\u00f3gica de muertes maternas 2024. Gobierno de M\u00e9xico. [Accessed August 6 2025].https:\/\/www.gob.mx\/salud\/documentos\/informes\u2010semanales\u2010para\u2010la\u2010vigilancia\u2010epidemiologica\u2010de\u2010muertes\u2010maternas\u20102024"},{"key":"e_1_2_9_13_1","unstructured":"Gobierno de M\u00e9xico. (2025).Informes semanales para la vigilancia epidemiol\u00f3gica de muertes maternas 2025. Gobierno de M\u00e9xico. [Accessed August 6 2025].https:\/\/www.gob.mx\/salud\/documentos\/informes\u2010semanales\u2010para\u2010la\u2010vigilancia\u2010epidemiologica\u2010de\u2010muertes\u2010maternas\u20102025"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.circen.2017.08.003"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-16-0495"},{"key":"e_1_2_9_16_1","article-title":"Interplay between baroreflex sensitivity, obesity and related cardiometabolic risk factors (review)","volume":"22","author":"Konstantinidou S.","year":"2021","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70185-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-024-07462-w"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez\u2010Reyna E. Dorantes\u2010M\u00e9ndez G. Esquivel\u2010Arizmendi G. A. &Reyes\u2010Lagos J. J.(2025).The impact of maternal obesity on fetal heart rate variability during labor: A non\u2010linear analysis. InXLVII Mexican conference on biomedical engineering(pp.419\u2013426).Springer.","DOI":"10.1007\/978-3-031-82123-3_40"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez\u2010Reyna E. Reyes\u2010Lagos J. J. Esquivel\u2010Arizmendi G. A. &Dorantes\u2010M\u00e9ndez G.(2025).The impact of maternal obesity on fetal autonomic function during labor: A preliminary analysis. InX Latin American conference on biomedical engineering(pp.213\u2013221).Springer.","DOI":"10.1007\/978-3-031-89514-2_18"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20021267"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236123"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.106"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.01.020"},{"issue":"6","key":"e_1_2_9_25_1","first-page":"2084","article-title":"Autonomic and hemodynamic responses to insulin in lean and obese humans","volume":"83","author":"Muscelli E.","year":"1998","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00355-1"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2010.11.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd8110152"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1119\/1.1475332"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.01792"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.248.1.H151"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/ad7777"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.76.1804"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.6.H2039"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-023-05632-3"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105187"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/e21030258"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014868"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-020-0627-2"},{"key":"e_1_2_9_40_1","article-title":"Cardio\u2010respiratory interaction and autonomic dysfunction in obesity","author":"Tonhajzerova I.","year":"2025","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","unstructured":"Viunytskyi O. &Shulgin V.(2017a).Fetal ECG and heart rhythm analyzing using BabyCard. In2017 Signal Processing Symposium(SPSympo 2017).","DOI":"10.1109\/SPS.2017.8053640"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","unstructured":"Viunytskyi O. &Shulgin V.(2017b).Signal processing techniques for fetal electrocardiogram extraction and analysis. In2017 IEEE 37th International Conference on Electronics and Nanotechnology (ELNANO) Proceedings (pp. 285\u2013289). IEEE.","DOI":"10.1109\/ELNANO.2017.7939772"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03898-z"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003990070035"},{"key":"e_1_2_9_45_1","unstructured":"World Health Organization (WHO).2016.Obesity and overweight. Fact sheet No. 311. Geneva: World Health Organization."},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S123935"}],"container-title":["Experimental Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/EP093339","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/EP093339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:27:50Z","timestamp":1786044470000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/EP093339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,25]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1113\/EP093339"],"URL":"https:\/\/doi.org\/10.1113\/ep093339","archive":["Portico"],"relation":{},"ISSN":["0958-0670","1469-445X"],"issn-type":[{"value":"0958-0670","type":"print"},{"value":"1469-445X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,25]]},"assertion":[{"value":"2025-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}