{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:22:06Z","timestamp":1782800526461,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["183969"],"award-info":[{"award-number":["183969"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Reduced cardiorespiratory fitness is common among breast cancer survivors and, although traditionally attributed to cardiac dysfunction, might also be related to peripheral skeletal muscle abnormalities. We examined peak and submaximal plantar\u2010flexion exercise and recovery kinetics for lower\u2010leg oxygen uptake (), blood flow and arteriovenous O\n                    <jats:sub>2<\/jats:sub>\n                    difference in 35 older, female long\u2010term breast cancer survivors (age, 70\u00a0\u00b1\u00a05\u00a0years; 14\u00a0\u00b1\u00a06 years post\u2010treatment) and 19 age\u2010 and sex\u2010matched healthy control subjects using MRI. The calf intermuscular fat to skeletal muscle ratio was evaluated using fat\u2010 and water\u2010separated MRI to quantify myosteatosis. No significant differences were found between groups for lower\u2010leg , blood flow or arteriovenous O\n                    <jats:sub>2<\/jats:sub>\n                    difference at peak or during submaximal plantar\u2010flexion exercise. Recovery kinetics for these measures were similar between groups (all\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &gt;\u00a00.05). No differences were found in calf muscle mass between breast cancer survivors and control subjects. A higher intermuscular fat to skeletal muscle ratio was significantly associated with reduced peak (cycle exercise) pulmonary  (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.37,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.01), lower plantar\u2010flexion power output (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.325,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.012) and delayed muscle  recovery kinetics in both groups (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.325,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.015). Older, female long\u2010term breast cancer survivors have comparable lower\u2010limb skeletal muscle oxidative capacity to control subjects. However, myosteatosis represents a key determinant of exercise performance and recovery kinetics regardless of breast cancer history. Interventions targeting skeletal muscle quality might be effective in improving both submaximal and maximal exercise tolerance and recovery kinetics in older women with or without a breast cancer diagnosis.\n                  <\/jats:p>","DOI":"10.1113\/ep093370","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T15:08:06Z","timestamp":1767884886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Postexercise muscle oxygen uptake kinetics in older breast cancer survivors and healthy individuals: Association with myosteatosis"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-7679","authenticated-orcid":false,"given":"Nathan R.","family":"Weeldreyer","sequence":"first","affiliation":[{"name":"Integrated Cardiovascular Exercise Physiology (iCARE) Laboratory, College of Health Sciences, Faculty of Nursing University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"McMurtry","sequence":"additional","affiliation":[{"name":"Integrated Cardiovascular Exercise Physiology (iCARE) Laboratory, College of Health Sciences, Faculty of Nursing University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Foulkes","sequence":"additional","affiliation":[{"name":"Integrated Cardiovascular Exercise Physiology (iCARE) Laboratory, College of Health Sciences, Faculty of Nursing University of Alberta  Edmonton Alberta Canada"},{"name":"Heart, Exercise and Research Trials Lab St Vincent's Institute of Medical Research  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Shewman","sequence":"additional","affiliation":[{"name":"Integrated Cardiovascular Exercise Physiology (iCARE) Laboratory, College of Health Sciences, Faculty of Nursing University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Pituskin","sequence":"additional","affiliation":[{"name":"Integrated Cardiovascular Exercise Physiology (iCARE) Laboratory, College of Health Sciences, Faculty of Nursing University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0163-9792","authenticated-orcid":false,"given":"Rachel J.","family":"Skow","sequence":"additional","affiliation":[{"name":"Integrated Cardiovascular Exercise Physiology (iCARE) Laboratory, College of Health Sciences, Faculty of Nursing University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging, Faculty of Medicine &amp; Dentistry, College of Health Sciences University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Grenier","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging, Faculty of Medicine &amp; Dentistry, College of Health Sciences University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre E.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Dentistry, College of Health Sciences University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Welsh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Dentistry, College of Health Sciences University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-2747","authenticated-orcid":false,"given":"Mark J.","family":"Haykowsky","sequence":"additional","affiliation":[{"name":"Integrated Cardiovascular Exercise Physiology (iCARE) Laboratory, College of Health Sciences, Faculty of Nursing University of Alberta  Edmonton Alberta Canada"},{"name":"Hochgebirgsklinik, Medicine Campus Davos  Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey R.","family":"Tomczak","sequence":"additional","affiliation":[{"name":"College of Kinesiology University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","first-page":"329","article-title":"Post\u2010exercise oxygen uptake recovery delay: A novel index of impaired cardiac reserve capacity in heart failure","volume":"6","author":"Bailey C. 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