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The cellular adaption of dendritic cells to reduced oxygen and nutrition levels at the site of infection is regulated predominantly by the transcription factor complex hypoxia\u2010inducible factor\u20101 (HIF\u20101). For a better understanding of the influence of dendritic HIF\u20101 on the outcome of a retroviral infection, we infected wild\u2010type and CD11c\u2010specific\n                    <jats:italic>HIF\u20101\u03b1<\/jats:italic>\n                    knockout mice with the murine Friend leukaemia virus (FV) to cause an acute to chronic infection. Chronic FV infection caused a much more severe clinical course in control mice than in knockout mice, although no gross differences in spleen weight and immune cell population during acute FV infection were observed. Following chronic FV infection, half of the control mice developed massive splenomegaly accompanied by a complete loss of splenic architecture, whereas the remaining control mice appeared able to control viral replication. In contrast, without exception all knockout mice were able to restrict viral replication. Furthermore, control mice showed increased numbers of antigen\u2010presenting cells with impaired activation and decreased adaptive immune response. Given that our knockout construct leads to an HIF\u20101\u03b1 protein without a functional DNA binding domain, and it was already shown that HIF\u20101\u03b1 plays a non\u2010transcriptional role in DNA replication, we analysed basal\n                    <jats:italic>HIF\u20101\u03b1<\/jats:italic>\n                    mRNA expression. All animals with a very low basal\n                    <jats:italic>HIF\u20101\u03b1<\/jats:italic>\n                    expression incurred FV recurrence, whereas higher basal expression was protective against recurrence. These results might indicate a novel role of HIF\u20101\u03b1 in control of chronic viral infections.\n                  <\/jats:p>","DOI":"10.1113\/ep093450","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T04:43:30Z","timestamp":1783313010000},"page":"3843-3856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dendritic cell\u2010specific hypoxia\u2010inducible factor\u20101\u03b1 deficiency protects mice from recurrent retroviral infection"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-3158","authenticated-orcid":false,"given":"Timm","family":"Schreiber","sequence":"first","affiliation":[{"name":"Institute of Physiology and Pathophysiology and Center for Biomedical Education and Research (ZBAF) University of Witten\/Herdecke  Witten 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