{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:33:15Z","timestamp":1793910795897,"version":"4.8.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL\u2010144723"],"award-info":[{"award-number":["HL\u2010144723"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic low\u2010grade inflammation characterizes type 2 diabetes mellitus (T2DM) and underlies the development of peripheral neuropathy, symptoms of which include mechanical allodynia and an exaggerated exercise pressor reflex. The purpose of this study was to determine whether mechanical allodynia and\/or specific concentrations of inflammatory mediators coincide with the presence of an exaggerated exercise pressor reflex. Haemoglobin A1c was assessed to detect diabetes onset (threshold \u22655.6%) in male University of California Davis (UCD)\u2010T2DM rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a018). Age\u2010matched, healthy Sprague\u2013Dawley rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a018) served as controls. Monthly measurements assessed mechanical allodynia (via paw withdrawal threshold), insulin and inflammatory mediators (via ELISA and multiplex kits). Paw withdrawal threshold was not different between groups prior to diabetes onset. However, by 8\u00a0weeks post\u2010onset, T2DM rats demonstrated a significant decrease in pain threshold compared to that before diabetes onset, which persisted for 8\u00a0weeks. This is the same period in diabetes progression as when the exercise pressor reflex is exaggerated. Prior to diabetes onset, UCD\u2011T2DM rats had significantly higher circulating levels of IL\u20116 and IL\u20111\u03b2, and these elevations persisted throughout disease progression, with only CRP showing a significant increase at 8\u00a0weeks post\u2011onset. These findings offer a useful foundation for further exploration into the assessments of mechanical allodynia and inflammation to determine when those with T2DM are at an increased risk for experiencing adverse cardiovascular events.\n                  <\/jats:p>","DOI":"10.1113\/ep093516","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:15:51Z","timestamp":1778030151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflammation, mechanical allodynia and an exaggerated exercise pressor reflex during disease progression in UCD\u2010type 2 diabetes mellitus rats"],"prefix":"10.1113","author":[{"given":"Michelle L.","family":"Harrison","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"McCuller","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"},{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amshula N.","family":"Gajula","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ybarbo","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Van Ryzin","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimber L.","family":"Stanhope","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Havel","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition University of California  Davis California USA"},{"name":"Department of Cellular and Physiological Sciences School of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0081-0244","authenticated-orcid":false,"given":"Audrey J.","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1113\/jphysiol.1937.sp003485","article-title":"Observation in man upon a blood pressure raising reflex arising from the voluntary muscles","volume":"89","author":"Alam M.","year":"1937","journal-title":"The Journal of Physiology"},{"issue":"5","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155944","article-title":"Effect of the IL\u20101 receptor antagonist Kineret\u00ae on disease phenotype in mdx Mice","volume":"11","author":"Benny Klimek M. 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