{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:14:27Z","timestamp":1789535667228,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["DC0190GP"],"award-info":[{"award-number":["DC0190GP"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000016","name":"Canadian Space Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020977","name":"Canadian Frailty Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals show that exercise can mitigate these effects, but evidence remains scarce and inconclusive in older adults. Therefore, the aim of this study was to evaluate the effects of a mixed\u2010exercise countermeasure on body composition, muscle volume, strength and quality in healthy, ageing adults during 2 weeks of head\u2010down tilt bed rest and in the subsequent recovery period, and to explore the underlying mechanisms. Twenty\u2010two participants (11\u00a0male and 11\u00a0female) aged 55\u201365 years completed the head\u2010down tilt bed rest protocol. Participants were randomly assigned to either an exercise group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a011) undertaking three daily exercise sessions or a passive\u2010mobilization control group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a011). Assessments of body composition, thigh muscle volume, muscle strength, blood markers and muscle biopsies were performed before, during and after bed rest, and after 4\u00a0weeks and 4 months of recovery. Bed rest induced significant declines in total and lower\u2010limb lean body mass, knee\u2010extensor strength and muscle quality. The mixed\u2010exercise intervention mitigated the loss of thigh muscle volume but did not prevent reductions in total or lower\u2010limb lean mass, strength or muscle quality. All participants had recovered fully after 4\u00a0weeks of recovery. In conclusion, daily participation in an exercise countermeasure preserves thigh muscle volume during 2 weeks of bed rest in healthy older adults but is insufficient to mitigate muscle strength and total lean mass.\n                  <\/jats:p>","DOI":"10.1113\/ep093524","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:41:21Z","timestamp":1774629681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of 14 days of head\u2010down bed rest and an exercise countermeasure on skeletal muscle atrophy, proteome and circulatory cytokines in older adults"],"prefix":"10.1113","author":[{"given":"Jean\u2010Christophe","family":"Lagac\u00e9","sequence":"first","affiliation":[{"name":"Faculty of Physical Activity Sciences Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Research Centre on Aging CIUSSS de l'Estrie \u2013 CHUS  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"St\u2010Martin","sequence":"additional","affiliation":[{"name":"Faculty of Physical Activity Sciences Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Research Centre on Aging CIUSSS de l'Estrie \u2013 CHUS  Sherbrooke Quebec Canada"},{"name":"Centre National de la Recherche Scientifique, Institut Pluridisciplinaire Hubert Curien UMR 7178 Universit\u00e9 de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Avino","sequence":"additional","affiliation":[{"name":"Bio\u2010informatic Platform, Department of Biochemistry and Functional Genomics Faculty of Medicine and Health Sciences Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Ghachem","sequence":"additional","affiliation":[{"name":"Faculty of Physical Activity Sciences Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Hajj\u2010Boutros","sequence":"additional","affiliation":[{"name":"Research Institute of McGill University Health Centre McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Morais","sequence":"additional","affiliation":[{"name":"Research Institute of McGill University Health Centre McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie S.","family":"McPhee","sequence":"additional","affiliation":[{"name":"Department of Sport and Exercise Sciences Manchester Metropolitan University  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Lambert","sequence":"additional","affiliation":[{"name":"PhyMedExp Universit\u00e9 de Montpellier, INSERM, CNRS  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00e9onor","family":"Riesco","sequence":"additional","affiliation":[{"name":"Faculty of Physical Activity Sciences Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Research Centre on Aging CIUSSS de l'Estrie \u2013 CHUS  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4381-1586","authenticated-orcid":false,"given":"Isabelle J.","family":"Dionne","sequence":"additional","affiliation":[{"name":"Faculty of Physical Activity Sciences Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Research Centre on Aging CIUSSS de l'Estrie \u2013 CHUS  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1123\/japa.2018-0093","article-title":"2,000 Steps\/Day does not fully protect skeletal muscle health in older adults during bed rest","volume":"27","author":"Arentson\u2010Lantz E.","year":"2019","journal-title":"Journal of Aging and Physical Activity"},{"issue":"8","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jamda.2013.05.021","article-title":"Evidence\u2010based recommendations for optimal dietary protein intake in older people: A position paper from the PROT\u2010AGE Study Group","volume":"14","author":"Bauer J.","year":"2013","journal-title":"Journal of the American Medical Directors Association"},{"issue":"4","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1748-1716.1993.tb09573.x","article-title":"Changes in lower limb muscle cross\u2010sectional area and tissue fluid volume after transition from standing to supine","volume":"148","author":"Berg H. 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