{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:01:13Z","timestamp":1790618473674,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Liver cirrhosis imposes a substantial global burden, with complications driving high mortality. Diet is pivotal in managing liver disease progression and cirrhosis\u2010related death. This study investigated associations between total fat intake, specific dietary fatty acid subclasses and all\u2010cause mortality in cirrhotic patients. In this prospective cohort study, 121 ambulatory patients with recently diagnosed cirrhosis (\u22646\u00a0months) were enrolled. Baseline dietary intake was evaluated via a validated 168\u2010item semi\u2010quantitative food frequency questionnaire. Participants were categorized into tertiles by total fat and fatty acid subclasses: saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), omega\u20103 and omega\u20106 fatty acids. Cox proportional hazards models computed hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted sequentially for age, sex, energy intake, BMI, smoking, alcohol use, cirrhosis aetiology, MELD score and Child\u2013Pugh class. During the 60\u2010month follow\u2010up, 50 deaths (41.3%) occurred. In fully adjusted models, highest versus lowest tertiles of total fat intake (HR\u00a0=\u00a06.69; 95% CI: 1.37\u201313.34;\n                    <jats:italic>P<\/jats:italic>\n                    \u2010trend\u00a0=\u00a00.017), SFA intake (HR\u00a0=\u00a08.2; 95% CI: 1.33\u201320.53;\n                    <jats:italic>P<\/jats:italic>\n                    \u2010trend\u00a0=\u00a00.014) and PUFA\u20106 intake (HR\u00a0=\u00a05.24; 95% CI: 1.1\u201326.44;\n                    <jats:italic>P<\/jats:italic>\n                    \u2010trend\u00a0=\u00a00.014) were independently associated with significantly elevated mortality risk. No significant associations were observed for MUFA, total PUFA or PUFA\u20103 intake. Kaplan\u2013Meier analyses confirmed significantly reduced 5\u2010year survival with higher total fat (log\u2010rank\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.003) and SFA intake (log\u2010rank\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001). In this exploratory prospective cohort study, higher intakes of total fat, saturated fatty acids and omega\u20106 polyunsaturated fatty acids were associated with increased all\u2010cause mortality among patients with cirrhosis. These preliminary findings are hypothesis\u2010generating and require confirmation in larger, adequately powered prospective studies.\n                  <\/jats:p>","DOI":"10.1113\/ep093526","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:38:30Z","timestamp":1790617110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between dietary fatty acids and all\u2010cause mortality in patients with cirrhosis: A cohort study"],"prefix":"10.1113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-027X","authenticated-orcid":false,"given":"Ali","family":"Jafari","sequence":"first","affiliation":[{"name":"Student Research Committee, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences  Tehran 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