{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:12:18Z","timestamp":1788757938575,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660307"],"award-info":[{"award-number":["81660307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060337"],"award-info":[{"award-number":["82060337"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Remote ischaemic preconditioning (RIPC) uses brief limb ischaemia to protect distant organs, but the mechanism of travel of the protective signal remains unclear. This study investigated whether endothelial cells (ECs) contribute to RIPC\u2010induced neuroprotection and the underlying mechanisms. Ten healthy volunteers (5 men, 5 women) underwent RIPC. Blood velocity was measured by Doppler ultrasound, and vascular wall pressure (VWP) was computed from 3D fluid\u2010structure interaction models based on magnetic resonance imaging data. Human microvascular endothelial cells (HMEC\u20101) were exposed to cyclic higher pressure (CHP) for five cycles. miR\u2010126 expression and promoter DNA methylation were assessed by real\u2010time PCR and bisulfite sequencing. DNA methyltransferases (DNMTs) and global methylation levels were measured. SH\u2010SY5Y neurons were incubated with exosomes from HMEC\u20101 culture medium and then subjected to oxygen\u2013glucose deprivation\/reperfusion (OGD\/R). Neuronal viability and apoptosis were evaluated by MTS assay and flow cytometry, and damage by spectrin and cleaved caspase\u20103 levels. Dicrotic waves were induced in 9 of the 10 participants following RIPC treatment. VWP transiently increased following RIPC. CHP reduced the expression and activity of DNMTs and induced the hypomethylation of the miR\u2010126 promoter sequence in HMEC\u20101 cells, leading to an increase in miR\u2010126 levels. Exosomes from CHP\u2010treated HMEC\u20101 cells decreased SH\u2010SY5Y cell injury under OGD\/R. RIPC transiently increased VWP in healthy volunteers. The results of this study indicate that CHP treatment may induce the production of neuroprotective molecules by ECs, which may protect against ischaemia\/hypoxia\u2010induced neuronal cell injury in vitro, possibly through a CHP\u2010induced effect involving miR\u2010126.<\/jats:p>","DOI":"10.1113\/ep093541","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:47:46Z","timestamp":1788756466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanical pressure on endothelial cells mediates remote ischaemic preconditioning\u2010induced neuroprotection via miR\u2010126"],"prefix":"10.1113","author":[{"given":"Xiaojie","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine Xuanwu Hospital Capital Medical University  Beijing PR 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Department The Second Affiliated Hospital of Baotou Medical College  Baotou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Ultrasound Imaging Department The Second Affiliated Hospital of Baotou Medical College  Baotou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine Xuanwu Hospital Capital Medical University  Beijing PR China"},{"name":"Inner Mongolia Key Laboratory of Hypoxic Translational Medicine Baotou Medical college  Baotou PR China"},{"name":"Center for Translational Medicine The Third People's Hospital of Longgang Clinical Institute of Shantou University Medical college (The Third People's Hospital of Longgang District Shenzhen)  Shenzhen PR 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Third People's Hospital of Longgang District Shenzhen)  Shenzhen PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-5076","authenticated-orcid":false,"given":"Guo","family":"Shao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine Xuanwu Hospital Capital Medical University  Beijing PR China"},{"name":"Inner Mongolia Key Laboratory of Hypoxic Translational Medicine Baotou Medical college  Baotou PR China"},{"name":"Center for Translational Medicine The Third People's Hospital of Longgang Clinical Institute of Shantou University Medical college (The Third People's Hospital of Longgang District Shenzhen)  Shenzhen PR China"},{"name":"Department of Neurosurgery The First Affiliated Hospital of Baotou Medical College  Baotou PR 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