{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:18:07Z","timestamp":1788290287774,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Head\u2010up tilt (HUT) and lower\u2010body negative pressure (LBNP) both reduce central blood volume but differ in heart orientation and regional fluid shifts. Whether they evoke comparable cardiovascular regulation when matched for preload remains uncertain. We characterized differences in fluid redistribution and haemodynamic responses during graded HUT and LBNP at intensities eliciting equivalent reductions in thoracic blood volume (TBV). In a randomized crossover design, 30 young adults (16 healthy control subjects and 14 with type 1 diabetes) underwent both HUT (22\u00b0, 42\u00b0, 58\u00b0 and 80\u00b0) and LBNP (\u221210, \u221220, \u221235 and \u221250\u00a0mmHg). Segmental bioimpedance, haemodynamic and ECG responses were recorded continuously. Equivalent reductions in TBV were obtained for\u00a022\u00b0 vs. \u221210\u00a0mmHg,\u00a042\u00b0 vs. \u221220\u00a0mmHg, and\u00a080\u00b0 vs. \u221235\u00a0mmHg\u00a0(all\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&gt;\u00a00.9). However, regional fluid shifts differed, in that HUT induced splanchnic pooling, whereas LBNP promoted pelvic pooling. At matched reductions in TBV, stroke volume decreased more during HUT than during LBNP (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.016). Cardiac output was maintained during HUT owing to more pronounced tachycardia, but it declined during LBNP at \u221235\u00a0mmHg. Type 1 diabetics exhibited consistently\u00a0higher heart rate across all conditions, but preserved stroke volume, cardiac output and mean arterial pressure relative to control subjects. Although HUT and LBNP generate comparable reductions in TBV, they elicit distinct cardiovascular adjustments. HUT engages gravitational influences that help to maintain cardiac output, whereas LBNP isolates baroreflex\u2010mediated responses, underscoring the unique contribution of gravity to orthostatic regulation. Collectively, these findings refine interpretation of orthostatic models and highlight their utility for detecting early reductions in autonomic reserve in type 1 diabetes.\n                  <\/jats:p>","DOI":"10.1113\/ep093588","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:44:38Z","timestamp":1785228278000},"page":"4089-4102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Haemodynamic responses to head\u2010up tilt versus lower\u2010body negative pressure in type 1 diabetes"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1039-0503","authenticated-orcid":false,"given":"Victorien","family":"Faivre\u2010Rampant","sequence":"first","affiliation":[{"name":"Inserm Comete, GIP Cyceron Normandie Univ, CHU Caen Normandie  Caen France"},{"name":"Department of Automatics, Biocybernetics, and Robotics Jozef Stefan Institute  Ljubljana Slovenia"},{"name":"Jozef Stefan International Postgraduate School  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Warnier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inserm Comete, GIP Cyceron Normandie Univ, CHU Caen Normandie  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Larmet","sequence":"additional","affiliation":[{"name":"Inserm Comete, GIP Cyceron Normandie Univ, CHU Caen Normandie  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0498-7095","authenticated-orcid":false,"given":"Damien","family":"Garcia","sequence":"additional","affiliation":[{"name":"INSERM research director at Creatis (Medical Imaging Research Laboratory) University of Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joubert","sequence":"additional","affiliation":[{"name":"Diabetes Care Unit Caen University Hospital, UNICAEN  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian Miles","family":"Bailey","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Faculty of Life Sciences and Education University of South Wales  Pontypridd UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-2159","authenticated-orcid":false,"given":"Igor","family":"Mekjavic","sequence":"additional","affiliation":[{"name":"Department of Automatics, Biocybernetics, and Robotics Jozef Stefan Institute  Ljubljana 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