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In order to examine potential differential metabolic responses to these tests, we characterized the (dis)agreement between OGTT\u2010 and MMTT\u2010derived indices of insulin sensitivity, insulin secretion and \u03b2\u2010cell function. We also described their convergent validity in individuals with normal glucose tolerance (NGT) or type 2 diabetes (T2D). We conducted a\n                    <jats:italic>post hoc<\/jats:italic>\n                    analysis of eight trials with participants who underwent either OGTT or MMTT, or both. Insulin sensitivity, insulin secretion and \u03b2\u2010cell function were derived. Agreement was assessed using Bland\u2013Altman regression approaches to estimate systematic and proportional bias and 95% limits of agreement. Linear mixed\u2010effects models were used to estimate means by glycaemic status (NGT vs. T2D), and area under the receiver operating characteristic (AUROC) curve analyses were used to evaluate discriminative ability between glycaemic status for the respective test indices. No systematic bias was observed. Proportional bias was present for insulin secretion and \u03b2\u2010cell function, with increasingly negative differences between methods (OGTT\u2013MMTT) as outcome values increased. All indices exhibited relatively wide 95% limits of agreement, which widened further at higher magnitudes. The OGTT\u2010 and MMTT\u2010derived means were significantly different between NGT and T2D. We did not observe differences in AUROC between tolerance tests. Agreement between OGTT\u2010 and MMTT\u2010derived indices worsened as the respective value increased, suggesting differential stimulus\u2013response characteristics in insulin secretion between tolerance tests. Despite this, descriptive analyses suggest that the test\u2010specific indices demonstrate convergent validity.\n                  <\/jats:p>","DOI":"10.1113\/ep093596","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:22:13Z","timestamp":1781691733000},"page":"3480-3491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["(Dis)agreement and concordance of metabolic indices from the oral glucose tolerance test and mixed\u2010meal tolerance test: Implications for application"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6564-4278","authenticated-orcid":false,"given":"Nina Sloth","family":"Nielsen","sequence":"first","affiliation":[{"name":"Centre for Physical Activity Research Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3598-2157","authenticated-orcid":false,"given":"Nikolaj","family":"Agerlin","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6368-2283","authenticated-orcid":false,"given":"Nikolas","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9105-5247","authenticated-orcid":false,"given":"Helga","family":"Ellingsgaard","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-4199","authenticated-orcid":false,"given":"Kristian","family":"Karstoft","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Bispebjerg and Frederiksberg Hospital University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1947-4252","authenticated-orcid":false,"given":"Louise Lang","family":"Lehrskov","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Oncology Copenhagen University Hospital \u2013 Herlev and Gentofte  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-4556","authenticated-orcid":false,"given":"Grit Elster","family":"Leg\u00e5rd","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1931-9658","authenticated-orcid":false,"given":"Mark Preben Printz","family":"Lyngb\u00e6k","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity Research Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Rheumatology Department of Internal Medicine 2 Holb\u00e6k Hospital  Holb\u00e6k Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-7079","authenticated-orcid":false,"given":"Beckey","family":"Trinh","sequence":"additional","affiliation":[{"name":"Clinic of Endocrinology, Diabetes and Metabolism University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0579-284X","authenticated-orcid":false,"given":"Thomas P. 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