{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:58:08Z","timestamp":1790877488916,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100021261","name":"Community Foundation of the Eastern Shore","doi-asserted-by":"publisher","award":["GR100269"],"award-info":[{"award-number":["GR100269"]}],"id":[{"id":"10.13039\/100021261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Physiology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We tested the hypothesis that two different durations of lower leg transcutaneous electrical nerve stimulation (TENS) increase post\u2010TENS popliteal artery blood flow (PABF), popliteal vascular conductance (PVC), and 6\u2010min walk distance (6MWD) in patients with peripheral artery disease (PAD). Seven subjects (5 male, 2 female) with PAD (67.9\u00a0\u00b1\u00a07.4 years; claudication: ankle\u2010brachial index (ABI) &lt;0.90) participated in three randomized treatment sessions: control or bilateral TENS (3.0\u00a0Hz burst mode, 250 \u00b5s) for either 15 or 45 min. PABF (Doppler ultrasound) was measured before and after treatment. 6MWD and time\/distance to claudication onset were measured 25\u00a0min post\u2010treatment during each session. PABF, PVC and 6MWD increased after both 15 and 45\u00a0min of TENS (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05, post\u2010TENS vs. pre\u2010TENS baseline\/control). Our preliminary results suggest that as little as 15\u00a0min of lower leg TENS increases leg blood flow and exercise capacity in individuals with PAD.\n                  <\/jats:p>","DOI":"10.1113\/ep093618","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:34:23Z","timestamp":1784655263000},"page":"4296-4302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute lower leg transcutaneous electrical nerve stimulation increases leg blood flow and exercise capacity in patients with peripheral arterial disease"],"prefix":"10.1113","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6229-7126","authenticated-orcid":false,"given":"Thomas K.","family":"Pellinger","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Maryland Eastern Shore  Princess Anne Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine B.","family":"Neighbors","sequence":"additional","affiliation":[{"name":"Sentara Center for Healthcare Simulation and Immersive Learning Virginia Health Sciences at Old Dominion University  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Hefta","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Maryland Eastern Shore  Princess Anne Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick H.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Maryland Eastern Shore  Princess Anne Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl B.","family":"Suarez","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Maryland Eastern Shore  Princess Anne Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erotokritos T.","family":"Varlas","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Maryland Eastern Shore  Princess Anne Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant H.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology &amp; Physiology University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-0208","authenticated-orcid":false,"given":"Brett J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Kinesiology &amp; Health Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318535"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12529-014-9408-4"},{"issue":"500","key":"e_1_2_10_5_1","first-page":"196","article-title":"Walking exercise in patients with intermittent claudication. Experience in routine clinical practice","volume":"54","author":"Bartelink M. E. L.","year":"2004","journal-title":"British Journal of General Practice"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-019-0350-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000967"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001005"},{"issue":"7","key":"e_1_2_10_9_1","first-page":"613","article-title":"Results of transcutaneous electrical stimulation (tes) in cure of lower extremity arterial disease","volume":"46","author":"Debreceni L.","year":"1995","journal-title":"Angiology The Journal of Vascular Diseases"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164116664287"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010512.pub2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X18762599"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.02.013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-1286"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X20902272"},{"issue":"2","key":"e_1_2_10_16_1","article-title":"Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: A systematic review and meta\u2010analysis of 381 studies (the meta\u2010TENS study)","volume":"12","author":"Johnson M. 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